Blood Therapy 2

Question 1

A single unit can be isolated from every units of donated blood by centrifuging the blood within the closed collection ystem to separate plts from rbc

Answer 1

Platelet concentrates

Question 2

As the plt number is inadequate Four to six units are pooled together called

Answer 2

Whole blood derived or random donor pooled plts

Question 3

Advantage of plts conc

Answer 3

Lower cost
Ease of collection
Processing

Question 4

Disadvantage of plt concentrate

Answer 4

Recipients exposure to multiple donor in a single transfusion and logistic issues related to bacterial testing

Question 5

Plts are collected in how many hours in apheresis procedure

Answer 5

2-3hrs

Question 6

In apheresis what are removed and what returned to donor

Answer 6

Plts and wbc removed, rbc and plasma returned

Question 7

A typical apheresis platelet unit

Answer 7

3 - 6 x10^11

Question 8

Advantage if single donor apheresis plts

Answer 8

Exposure of the recipient to a single donor rather than multiple donor

Ability to match donor and recipients characteristics such as HLA, Cmv, and blood type certain recipients

Question 9

Which contain less than 5x10^6 leukocytes

Answer 9

Plts, pooled, buffy coat deried, leucocyte depleted pool pf plts, derived from buffy coat

Question 10

A single donor plt component containing less than 5x10^6 leucocytes

Answer 10

Plts, apheresis, leucocyte depleted

Question 11

This component indicated for pt with reaction to plasma containing components

Answer 11

Pksts, suspended in additive, keukocyes depleted, plts concentrate,

Question 12

Volume of pc

Answer 12

150-450ml

Question 13

Ph of pc

Answer 13

Bet 6.4-7.4

Question 14

Leuko ct in pc

Answer 14

Less than 5x10^6

Question 15

Shelf life of pc

Answer 15

5 days

Question 16

Practical shelf life of pc

Answer 16

2.3-3days

Question 17

Pkts ar stored in

Answer 17

Room temp

Question 18

Cold induces

Answer 18

Clustering of vwf receptor kn tge plt surface and morphological changes of plts

Question 19

Leading to enhanced

Answer 19

By hepatic macrophages and reduced plts survival in the recipients

Question 20

Plts are stored at a core temp of

Answer 20

22deg +/- 2 deg with agitation for 5 days in closed system

Question 21

Plts are stored in room temp to engabce

Answer 21

Bacterial growth and third leading cause of HTR

Question 22

For any pt who develop a fever within 6 hrs after receiving plts

Answer 22

Sepsis from plts considered

Question 23

One plt concentrate is usually given to most

Answer 23

Adukt pt

Question 24

In small childern dec 20kgs and 10-15ml

Answer 24

One plt conc used

Question 25

In older children

Answer 25

An adukt dose of plts should be used

Question 26

One plt comc ususlly produces and increase of approx how many plts and how many kg in pt

Answer 26

7000-10000mm3 at 1 hr to 70kg

Question 27

Ten units f plt concentrate are required to inc plt ct by

Answer 27

100000 cells/mm3

Question 28

Dose computation

Answer 28

PI X BV X F-1

Question 29

Prepared from whole blood by separating snd freezing plasma 200-250'l within 6hr donation

Answer 29

Fresh frozen plasma

Question 30

Ffp may be stored up to and how many deg

Answer 30

1yr -18 deg

Question 31

It contains aol coagulation factors and othe protein

Answer 31

Ffp

Question 32

Order the ffp should be what

Answer 32

30-37 deg with constant agitation

Question 33

After thawing of ffp can be stored at what temp and what if room temp

Answer 33

4deg for 24hrs but if room temp 4hrs

Question 34

Diff types of ffp

Answer 34

``` Fresh frozen plasma F24plasma Cryosupernatant Liquid plasma Solvent detergent treated plasma ```

Question 35

Plasma frozen at 18 deg within 6hrs of donation

Answer 35

Ffp

Question 36

Plasma frozen at 18det within 24 hrs cryosuoernatant and solvent detergent treated plasma liquid

Answer 36

F24 plasma

Question 37

Teh plasma remaining after removing cryoprecipitate

Answer 37

Cryosupernatant

Question 38

Cryosupernatant also referrref as

Answer 38

Cryo poor plasma

Question 39

Spused as plama replacement in pt with thrombicytopenic purpura

Answer 39

Cryosupernatant

Question 40

Vitamin def correction of major bleeding in the setting of

Answer 40

Warfarin coagulation

Question 41

Remival of cryoprecipitate from plasma does nit deplete

Answer 41

Vut k dependent clotting factors

Question 42

Plasma nit immmediately frozen as ffp or f24 and stored at 1-6deg

Answer 42

Liquid plasma

Question 43

Used preparation of plasma derivative slike albumin, factor conc, abd immuniglobulins

Answer 43

Liquid plasma

Question 44

Treatment of pooled plasma prior o freezing with a solvent and non ionic detergent inactivates a number of lipid envelope virus, hiv, hep b and c

Answer 44

Somvent detergent palsma

Question 45

Non enveloped viruses like parvob19 and hep a arenot inactivated by this process and prions

Answer 45

S/d plasma

Question 46

This method used ti inactivate viruses in ig and coagulation factors

Answer 46

S/d plasma method

Question 47

Has similar levels of most clotting factors and similar hemostatic properties as standard ffp

Answer 47

S/d plasma

Question 48

Twi emthod to collect this component

Answer 48

Random donor pooled pt | Single donor apheresis platelets

Question 49

The inuitial therapeutic dose of ffp average

Answer 49

10-15ml/kg to obtain 30% factor

Question 50

Repeating dosing should follow the resukt pf serial diagnostic coagulation test such as

Answer 50

Pt and aptt

Question 51

Ffp in trauma

Answer 51

Tarditional method fluids, ffp, rbc only abnormal coagulation result problem dikutional coagulopathy resulting in prolonged microvascular bleeding Recent studies show improved outcomes with higher ration of cell unit to ffp 3:2

Question 52

Cryoprecipitate Originally it was a developed as a therapy for

Answer 52

Hemophilia A

Question 53

Cryoprecipitate enrinched with

Answer 53

Fibrinogen, fac 8, vwf, factor 13

Question 54

When ffp is thawed at 4 deg

Answer 54

Prrcipitate formed, resuspend snall volume of plasma and refrozen 18deg for 1 year

Question 55

1 unit of whole blood contains

Answer 55

250 ml plasma

Question 56

One unit of cryoprecipitate volume cobtains 10-20ml in to

Answer 56

150-250 mg

Question 57

80-100 units of

Answer 57

Factor 8

Question 58

50-100 units of factor

Answer 58

13

Question 59

50-60mg of

Answer 59

Fibronectin

Question 60

40-70% of

Answer 60

Vwf conc

Question 61

Essential for the fromation promary hemostatic plus maintanance of normal hemostasis

Answer 61

Plts

Question 62

Thrombocytopenia may csused

Answer 62

Dec plt production Increase destruction Massive transfuison

Question 63

Dic

Answer 63

Increase destruction

Question 64

Because of rapid use of olt for hemostasis and dilution plt by resuscitation fouids

Answer 64

Massive transfuison

Question 65

After chemotherapy or malignancy

Answer 65

Dec plt prodyction

Question 66

Indicated for patients

Answer 66

Who are bleeding due to thrombipocytopenua Who have abnormal fuctioning Who have plt ct under 20000 ul Who have undergone chemotherapy, dic, massive transfusion