Bone in Class Presentation Flashcards Preview

Rheum/Musculoskeletal/Derm Week 1 > Bone in Class Presentation > Flashcards

Flashcards in Bone in Class Presentation Deck (21):
1

Bone malignancies are fairly uncommon. What is one common?

liomyomas of the uterus (especially in AA women)

as well as lipomas

2

When you see mixed osteolytic and osteoblastic lesions in a female, think:

metastatic breast cancer

3

What patient population is common for osteosarcoma?

mostly children and some older than 60

4

A positive TTF-1 indicates what?

adenocarcinoma of the lung

5

GATA-3 is positive in what?

breast tumors and urothelial bladder tumors

6

What metastatic cancers to bone have blastic/sclerotic lesions (hyper dense-whiter)?

prostate (induce bone growth)

7

What metastatic cancers to bone have purely lytic lesions (blacker)?

kidney, thyroid, lung

8

Ewing's sarcomas are almost always positive for what?

CD99 (not specific)

9

Other tests for Ewing's sarcoma?

a FISH-based for 22q12 rearrangement and a PCR-based test for the discrimination of the Type 1 and Type 2 forms of the EWS-FLI1 translocations

10

Common situational cause of rickets?

mom has two children and the earlier born one doesnt get as much breast milk once the other is born

11

What is the defect in osteogenesis imperfecta?

type 1 collagen

12

Paget disease is a disease of _____

osteoclasts

13

Possible cause of Paget disease?

viral infection (paramyxovirus) in association with genetic susceptibility

14

What are the three phases of Paget disease?

1) lytic (incipient active)- dominated by osteoclast activity

2) mixed (active)- balanced osteoblast/clast activity

3) sclerotic/blastic (late inactive)

15

What are the serum markers for Paget disease?

-elevated ALP
-normal Ca2+ and phosphorus
-urine hydroxyproline increased

16

How does primary syphilis present?

painless chancre

17

How does secondary syphilis present?

-palmar rash
-LAD
-condyloma latum
-neurosyphilis (usually asymptomatic)

18

Next step of syphilis?

latent

19

What follows latent syphilis?

neurosyphilis, with aneurysms and gummas

20

What are some potentials morbidities associated with congenital syphilis in infants?

rash, osteochondritis, periositis, and liver/lung fibrosis

21

What are some potentials morbidities associated with congenital syphilis in childhood?

-Interstitial keratitits
-Hutchinson teeth
-CN XIII deafness