Drug-Induced Lupus Flashcards Preview

Rheum/Musculoskeletal/Derm Week 1 > Drug-Induced Lupus > Flashcards

Flashcards in Drug-Induced Lupus Deck (11):
1

What environmental factors are definitely linked to increased risk of SLE?

-ultraviolet B light

2

What endogenous molecules are probably linked to increased risk of SLE?

estrogen and prolactin

3

What drugs are probably linked to increased risk of SLE?

-Hydralazine*
-Procainamide*
-Isoniazid*
-Hydrantoinds
-Chlorpromazine*
-Methyldopa
-TNFa inhibitors*
-Interferon A
-Penicillamine
-Minocycline

PITCH PIM PM

4

What viruses are probably linked to increased risk of SLE?

EBV

5

What dietary foods are probably linked to increased risk of SLE?

-Alfalfa sprouts (canavanine foods)
-vitamin D deficiency

6

Other things probably linked to increased risk of SLE?

-smoking
-human retroviruses
-bacterial DNA (causing anti-DNA Abs)

7

What drugs are currently (Sept 2016) Available for SLE?

-corticosteroids
-cyclophosphamide
-methotrexate
-mycophenolate mofetil
-Azathrioprine
-Hydroxychloroquine
-Belimumab

8

Presentation?

most common to least: arthralgia, arthritis, fever, and rash

no nephritis (unless TNFa antagonist drug induced)

9

Patient population for drug-induce lupus?

most commonly seen in young women being treated for acne

10

Pathogenesis

genetic susceptibility needed with a precipitating environmental and/or behavior trigger

11

What is Belimumab?

humanized monoclonal against BLYS (B-lymphocyte stimulator). Not that effective.