Bone ossification

Question 1

How is long bone formed endochondral?

Answer 1

Cartilage precursor
1) Mesenchymal cells condense into cartilaginous collagen
2) Endochondral ossification
3) Blood supply- angiogenesis
4) Secondary ossification at ephysis
5) Formation growth plate
6) Growth plate turned bone- can’t grow

Question 2

What precursor for long bone formation?

Answer 2

Cartilage

Question 3

Explain formation long bone?

Answer 3

1) Mesenchymal cells differentiate into chondroblasts
2) Chondrocytes deposit ECM and hyaline cartilage
2) Osteoblasts deposit bone, replace hyaline cartilage
3) Primary ossification centre
4) Bone replaces hyaline cartilage
5) Secondary ossification centre
6) Epiphyseal plate- hyaline cartilage between epiphysis and diaphysis

Question 4

Outline process of intramembranous ossification in flat bones?

Answer 4

1) Mesenchymal cells differentiate into osteoblasts
2) Osteoblasts deposit matrix which becomes mineralized
3) Osteoid formation
4) Immature woven trabeculae deposited
5) Replaced secondary then primary cortical bone
4) Mineralisation of osteocytes

Question 5

What are two types of ossification?
Involved in what?

Answer 5

Endochondral- long bone (cartilage then bone)
Intramembranous- flat bone (straight bone)

Question 6

Function osteoblast and osteoclast in trauma?

Answer 6

Osteoblast- new woven bone, lay down lamella bone
Osteoclasts- mop up dead bone, remodel strong bone