Regulation bone Flashcards
1
Q
State 2 things that regulate bone activity?
A
1) Osteoclast driven- RANK ligand/OPG balance
2) Osteoblast driven- cytokines
2
Q
What drives osteoblasts?
A
Cytokines
3
Q
What drives osteoclasts?
A
RANKligand/OPG balance
4
Q
What does OPG stand for?
A
Osteoprotegerin (OPG)
5
Q
What can excess OPG lead to?
A
Dense bones
6
Q
Function OPG?
A
Protects bone from excessive resorption
Bind rank ligand- inhibit osteoclast activity
7
Q
What will decrease resorption (breakdown) bones?
A
OPG
8
Q
What promotes breakdown bones?
A
Rank ligand
9
Q
What do cytokines drive?
A
Osteoblasts
10
Q
What stimulates osteoclast formation?
A
RANK ligand
