Boner Pills and BOTOX

Question 1

boner pill mech of action

Answer 1

• cGMP phosphodiesterase type 5 (PDE-5) inhibitor

- prevents cGMP breakdown by PDE-5

Question 2

boner pill side effect

Answer 2

• hypotension
• refractory HR increase
• problems with pre-existing CV disease
• Visual disturbances?
• auditory disturbances

Question 3

boner pill pharmacokinetics

Answer 3

• oral aministration
• —>sildenafil/vardenafil=1 hr pre-coitus
• —>tadalafil=36 hr duration
• CYP3A4 metabolism (many drug interactions)
• renal/hepatic disease=dosage adjustment

Question 4

boner pill drug interactions

Answer 4

• drugs metabolized by CYP3A4
• vasodilators (nitrates, a-blockers, Ca-blockers)
• sympathomimetics

Question 5

Sildenafil (Viagra) pharmacokinetics

Answer 5

onset: 30 min
duration: 4 hrs

Question 6

Vardenafil (Levitra) pharmacokinetics

Answer 6

onset: 30 min
duration: 4 hrs

Question 7

Tadalafil (Cialis)

Answer 7

onset: 45 min
duration: 36 hrs

Question 8

Botulinum toxin

Answer 8

• Clostridium botulinium
• no acetylcholine release from nerve endings
• death from diaphragmatic paralysis
• BOTOX