drug main uses (Beta Blockers)

Question 1

Acebutolol (Sectral)

Answer 1

B1 (Cardioselective)

Competitive antagonism of B1 receptor

Lipid sol: L
partial agonist: yes
membrane stabilizing: yes

Decreased HR, Contractility, Automaticity, Conduction velocity; Decreased myocardial O2 deficit and cardiac output (decreased rate and contractility); Decreased renin secretion (B1 in JG Cells); Protection from thyroid storm and pheochromocytoma.

Question 2

Atenolol (Tenormin)

Esmolol (Brevibloc)

Answer 2

B1 (Cardioselective)

Competitive antagonism of B1 receptor

Lipid sol: L
partial agonist: no
membrane stabilizing: no

Decreased HR, Contractility, Automaticity, Conduction velocity; Decreased myocardial O2 deficit and cardiac output (decreased rate and contractility); Decreased renin secretion (B1 in JG Cells); Protection from thyroid storm and pheochromocytoma.

Question 3

Metoprolol (Lopressor, Toprol-XL)

Answer 3

B1 (Cardioselective)

Competitive antagonism of B1 receptor

Lipid sol: M
partial agonist: no
membrane stabilizing: yes

Decreased HR, Contractility, Automaticity, Conduction velocity; Decreased myocardial O2 deficit and cardiac output (decreased rate and contractility); Decreased renin secretion (B1 in JG Cells); Protection from thyroid storm and pheochromocytoma.

Question 4

Nadolol (Corgard)

Answer 4

B1 & B2 (Non-selective)

Competitive antagonism of B1 & B2 receptors

Lipid sol: L
partial agonist: no
membrane stabilizing: no

Enhancement of B1 agonist effects

Question 5

Pindolol

Answer 5

B1 & B2 (Non-selective)

Competitive antagonism of B1 & B2 receptors

Lipid sol: M
partial agonist: yes
membrane stabilizing: yes

Enhancement of B1 effects

Question 6

Propanolol (Inderal-LA)

Answer 6

B1 & B2 (Non-selective)

Competitive antagonism of B1 & B2 receptors

Lipid sol: H
partial agonist: no
membrane stabilizing: yes

Enhancement of B1 effects

Question 7

Timolol (Timoptic)

Answer 7

B1 & B2 (Non-selective)

Competitive antagonism of B1 & B2 receptors

Lipid sol: M
partial agonist: no
membrane stabilizing: no

Treats glaucoma by decreasing aqueous humor production and thus IOP.

Question 8

Labetalol (Trandate)

Answer 8

B-blocker and a-blocker

Rapid decrease of arterial pressure from B antagonism and a-antagonist-induced decrease in peripheral arterial resistance