Direct acting sympathomimetics (adrenergic agonists)

Question 1

Epinephrine

Answer 1

a1=a2=b1=b2

• inc HR/force
• bronchodilation

main use: anaphylactic shock

Question 2

Norepinephrine

Answer 2

a1=a2=b1»b2
-vasoconstriction w/ BP rise and bradycardia

main uses:

BP support during anesthesia
neurogenic shock
septic shock
cardiogenic shock

Question 3

Isoproterenol

Answer 3

b1=b2»all others

main use: diagnosis of unexplained syncopes

Question 4

Dopamine

Answer 4

D receptors>b1>a1»all others
-blood flow to GI/kidney at low dose

main uses:
shock
CHF
treat bradycardia