Bones II Flashcards
(50 cards)
In situations of bone loss, ex: ostopenia, osteoporosis, bone lysis, what takes up the newly created space?
- existing tissue expands or loosens
- may include fluid ex: serous atrophy of fat
- replaced by fibrous tissue
Two concepts Allen likes:
- in order to diagnose a specific disease, you have to know that the specific disease exists
- the diagnosis of a bone disease requires the recognition of a pattern of bone loss, bone production, or both
Bone is susceptible to the same pathologic processes as ither tissues & organs, what are these?
- alterations of growth (aplasia, hypoplasia, atrophy, hyperplasia, neoplasia)
- circulatory disorders (hemorrhage & ischemia)
- inflammation & repair
- degeneration & necrosis
Sometimes in bone the pathologic processes like other tissues are overshadowed by underlying & more intuitive concepts concerning the pathogenesis of a lesion or disease: examples of this?
- trauma leading to a fracture
- nutritional or metabolic disorders leading to so-called metabolic bone disease
- like other organs, bone has a limited range of reactions to injury & mechanisms of repair
Which two processes that usually occur together are involved in the reaction of bone to injury?
- removal of damaged bone (resorption or lysis)
- production of new bone
- the proportion of these two reactions will vary
Injury to the periosteum (& endosteum) will usually be followed by?
formation of periosteal (& endosteal) new bone
Bone density will change in response to?
change in use
How is bone related to calcium & phosphorus?
- bone is a body’s main reservoir of calcium (~99%) & phosphorus (~85%) & is involved in plasma calcium & phosphorus homeostasis
- therefore, bone is affected by any disease involving abnormal calcium & phosphorus metabolism, including disorders of nutritional origin
What is a fracture?
- a break or rupture in a bone
- a common occurrence
- represents a physical discontinuity in a bone which results in instability & pain
- which may manifest as impaired movement (lameness, immobility, or recumbency)
What kind of fracture is this?
Greenstick
What kind of fracture is this?
spiral
What kind of fracture is this?
Comminuted
What kind of fracture is this?
Transverse
What kind of fracture is this?
compound
What is happening here?
vertebral compression
- What is the pathogenesis of fractures?
fractures occur under one of two circumstances:
1. either a normal bone fractures under excessive force - TRAUMATIC FRACTURE
2. or an abnormal bone fractures under normal force - PATHOLOGIC FRACTURE
What is fracture repair?
the healing of a fractured bone
What is the process of fracture repair?
- can be conveniently divided into 5 phases
- but important to appreciate that the divisions are arbitrary, they overlap & are concurrent, they may occur at different rates in different areas of a fracture, & they represent a summary of a complex & incompletely understood process
What are the 5 phases of fracture repair?
Phase I - Injury & Inflammation
Phase II - Organization of the Hematoma
Phase III - Callus formation: External & internal callus
Phase IV: Callus remodeling
Phase V: Callus modeling
What is phase I of fracture repair?
Injury & Inflammation
- when bone is fractured there is tearing of the periosteum & endosteum, rupture of blood vessels of the bone, & injury to surrounding soft tissue
- these events result in ischemic necrosis of bone at the fracture lines & associated marrow, formation of a hematoma, & inflammation
- these changes promote the immediate activation & recruitment of platelets, macrophages, & other leukocytes, all of which release growth factors
What is phase II of fracture repair?
Organization of the hematoma
- w/in 24-48 hrs, the hematoma btwn bone fragments begins to organize
- undifferentiated mesenchymal cells of the periosteum, endosteum, & bone marrow are activated, proliferate, & invade the hematoma
- similarly, endothelial cells proliferate to form new blood vessels, aka, neovascularization
What is phase III of fracture repair?
Callus formation: internal & external callus
- mass of exudate & CT that forms around a fracture during repair is called a callus or primary callus
- there is an external callus & an internal callus
- the external callus is usually more substantial (& easily noticed) w/ the periosteum making an important contribution
- where the blood supply is adequate & the oxygen tension is high (away from the fracture gap), undifferentiated mesenchymal cells become osteoblasts that produce (de novo) woven bone
- where the blood supply is poor & the oxygen tension is low (at or near the fracture gap), undifferentiated mesenchymal cells become fibroblasts & chondroblasts
- the cartilage produced by the chondroblasts is later REPLACED by woven bone via endochondral ossification
- the internal callus is produced by the endosteum & is formed in the same manner as the external callus
- it is usually smaller than the external callus & may temporarily occlude the medullary space
How quickly does callus formation occur?
- may begin w/in 24 hrs
- woven bone may be visible MICROSCOPICALLY as quickly as 36 hrs after fracture, but may not be visible RADIOGRAPHICALLY for 2 weeks
- under favourable conditions, it takes 4-6 wks for the primary callus to be replaced by a so-called bony callus
What causes the time for callus formation & remodeling to vary?
- animal’s age & health (including nutrition), the fracture type & location, associated injuries & infection, & the method & quality of fixation, if any