Flashcards in BPH and ED Deck (20)
Population related risks for prostate enlargement
BPH more common in American/Australian and less common in Asian cultures
Tests and exams for diagnosis of BPH
AUA symptom index, DRE, neuro exam, UA, PSA
Relax smooth muscle of the prostate and bladder neck without interfering with bladder contractility.
Decrease bladder resistance to urinary outflow
Work quickly and increase urinary flow
α-blockers , Alpha-1 adrenergic antagonists
Major side effect of α-blockers , Alpha-1 adrenergic antagonists
Name the α-blockers , Alpha-1 adrenergic antagonists
tamsulosin (flomax), doxazosin (cardura), Terazosin (Hytrin)
α-blockers , Alpha-1 adrenergic antagonist that causes less orthostatic HTN/fluid retention but may cause floppy iris syndrome
α-blockers , Alpha-1 adrenergic antagonist that may have secondary benefit to patients with cardiac dz
α-blockers , Alpha-1 adrenergic antagonist often used for HTN and should be taken at bedtime to avoid hypotension
Blocks 5-alpha reductase, the enzyme that activates testosterone in the prostate.
Impairs prostate growth by inhibiting the conversion of testosterone to dihydrotestosterone
What zone of the prostate doe 5-α-Reductase inhibitors
cause changes in the epithelial cells?
Name the 5-α-Reductase inhibitors
Finasteride (Proscar) and Dutasteride (Avodart)
Antagonizes acetylcholine receptors. Used to help urgency symptoms by stabilizing the detrusor muscle
Herb derived from dark berries of a palm tree. Inhibits testosterone conversion to DHT. Stops DHT at receptor sites
Vitamin that may prevent or decrease prostate enlargement
Name the PDE-5 inhibitors
Sildenafil (Viagra), Vardenafil (Levitra), Tadalafil (Cialis)
Work by blocking the action of type 5 phosphodiesterase maintaining vasodilation and increased blood flow to the penis
What should be avoided in patient who is taking a PDE-5 inhibitors due to sharp decrease in BP?
Use for patients with ED who have contraindications to 5 PDE inhibitors. Available as intracavernosal injection or intraurethral suppository
Should be avoided in patients with leukemia, myeloma, or sickle cell anemia or sickle cell trait