Breast Flashcards

1
Q

ducts and lobules are lined by ___ and ___ cell layers

A

luminal
myoepithelial

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2
Q

acute mastitis due to ___ ___

A

s aureus

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3
Q

periductal mastitis

A

associated with smokers
(due to squamous metaplasia)

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4
Q

green/brown nipple discharge
plasma cells in biopsy

A

mammary duct ectasia

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5
Q

Ex. Premenopausal woman with lumpy, “blue dome” appearing breast tissue

A

fibrocystic change

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6
Q

Ex. Premenopausal woman with bloody nipple discharge WITH myoepithelial cells on biopsy

A

intraductal papilloma

(carcinoma is WITHOUT myoepithelial cells on biopsy)

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7
Q

fibroadenoma relevance

A

NO risk for cancer

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8
Q

“leaf-like projection” on biopsy

A

phyllodes tumor

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9
Q

breast cancer prevalence

A

2nd most common mortality (lung)

most common cancer

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10
Q

necrosis and dystrophic calcification in the center of the ducts

A

DCIS

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11
Q

IDC presents as what?

A

mass with skin dimpling/retraction

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12
Q

duct-like structures in desmoplastic stroma on histology

A

IDC

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13
Q

myoepitheal cells are ___ in carcinoma

A

absent

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14
Q

inflammatory carcinoma (IDC)

A

carcinoma in dermal lymphatics
poor prognosis

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15
Q

inflammatory carcinoma (IDC) presents as what? (can be confused with what)

A

inflamed breast (appears as mastitis, but no improvement with AB)

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16
Q

BRCA1 mutations associated with ___ carcinoma (IDC)

A

medullary

17
Q

grows in single-file pattern and shows signet-ring morphology

A

ILC

18
Q

ER/PR+ Tx

A

Raloxifene

19
Q

HER2/neu+ Tx

A

trastazumab

20
Q

BRCA2 relevance

A

males

21
Q

male breast cancer presents in the ___ region

A

subareolar

22
Q

male breast cancer associated with ___ ___

A

klinefelter syndrome

23
Q

female breast cancer presents in the ___ region

A

superolateral