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Flashcards in breast Deck (47)
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1

name the most common disorder of the breast?

fibrocystic disease

2

what are the 3 forms of fibrocystic disease of the breast?

non-proliferative
proliferative
sclerosing adenosis

3

what are some special lab findings of non-proliferative fibrocystic breast tissue

dilation of ducts with no epithelial hyperplasia.
&
Increase in collagen

4

what is the color of a fibrocystic cyst (non-proliferative) when removed ?

blue/brown

5

what are some special lab findings of proliferative fibrocystic breast tissue?

epithelial hyperplasia
ductal papillomatosis
fenestrations
increase risk of carcinoma

6

what are the findings of ductal papillomatosis?

multilayered with papillary folding

7

what are the findings with fenestration of breast tissue?

filling of the ductal lumen

8

what form of fibrocystic breast disease can you find papillomatosis and fenestrations?

proliferating form

9

what is special about sclerosing adenosis?

*looks like carcinoma of the breast*
adenosis
intralobular sclerosis
enlarged and deformed lobular units
proliferation of acini

10

what does adenosis mean?

the number of acini per duct is increasing

11

is which form of fibrocystic disease of the breast can you find an increase of acini per duct and intralobular fibrosis?

sclerosing adenosis

12

what is the most common benign tumor of the breast?

fibroadenoma

13

what is special about a fibroadenoma?

it is hormone dependent.
responds to increase of estrogen
multiple and bilateral

14

if a women comes to the clinic with a free moveable mass on her breast what should be on the top of your differential dx.?

fibroadenoma

15

after taking a biopsy of a free moveable mass of a woman's breast what should you expect to see?

intact BM
loose fibroblastic stroma
can either appear:
periductal or intraductal

16

in a lab finding you see a periductal mass meaning it is what shape

round or oval

17

in a lab finding you see a slit like mass what shape is it?

slit like

18

in a lab finding you see a slit like mass with loose stroma and an intact BM what tumor of the breast is it?

intraductal fibroadenoma

19

what is the name of a epithelial tumor of the breast

intraductal papilloma

20

what are the two main locations of a intraductal papilloma?

lactiferous ducts and the aerola

21

what are some special findings of a intraductal papilloma?

mostly solitary
branching papillae covered with cubical epithelium
neoplastic papillary growth

22

are intraductal papilloma benign or mets?

benign

23

what are some clinical findings of a intraductal papilloma?

bloody nipple discharge
unilateral
subaerolar mass

24

what is the second leading cancer in america

carcinoma of the breast

25

a lady comes into the clinic an immoveable mass in breast
early menarche
late menopause
and used birth control for several years
what is she most likely to have?

carcinoma of the breast

26

what are some classical findings of breast carcinoma?

ductal or lobular epithelium
left breast involved
upper outer quadrants

27

where can non-invasive carcinomas be found?

in the basement membrane

28

out of the non-invasive carcinomas;
is intraductal or intralobular carcinoma of the breast most common?

intraductal is most common

29

what are some classic lab findings of intralobular carcinoma?

*plugged and filled ducts
* confined to BM
* comedocarcinoma = central necrosis of ducts
*rapid proliferation

30

you find central necrosis of ducts
plugging and filling of ducts
and rapid proliferation of cells (mitotic figures) in tissues what carcinoma of the breast is it most likely?

intraductal carcinoma of the breast

31

during a mammogram you incidentally find clusters of acini that are monomorphic what kind of carcinoma of the breast is it?

lobular

32

what is the treatment for both the intralobular or intraductal forms of non-invasive carcinoma?

lumpectomy

33

the majority of invasive breast carcinomas are

ductal

34

pt. comes into the clinic with a hard immoveable mass on the outer quadrant of the left breast with an 'orange' look with dimpling and a retracted nipple.... what should be on the top of your differential?

invasive ductal carcinoma

35

in the lab biopsy of a invasive ductal carcinoma what would likely be seen?

nests and cords of malignant cells in stroma
replacement of breast fat with fibrosis

36

what are the variants of ductal carcinoma?

medullary
colloid
tubular

37

microscopically the dr. finds large fleshy groups of cells separated by scant fibrous tissue and infiltration of lymphocytes what type of ductal carcinoma is it?

medullary

38

out the 3 types of ductal carcinoma which one has the best prognosis?

medullary

39

microscopically the dr. finds mucin intracellularlly and extracellulary with a blue/gray bulky mass...
what kind of ductal carcinoma is this?

medullary

40

microscopically you find well formed tubules... what kind of ductal carcinoma of the breast is this?

tubular ductal

41

pt. comes into office with nipple lesion and the lab finds it extending into the ductal system and does not cross the BM
they also note a 'halo' look?

what kind of disease of the breast is this?

paget's disease
due to an existing tumor of the breast (non-invasive or invasive)

42

what are some special lab findings of pagets disease?

*clear halo-- mucopolysaccharide
* DOES NOT cross BM
*invades the ductal system

43

what is a special lab finding of invasive lobular carcinoma?

indian file line

44

you find mitotic cells invading 'individually' into the stroma --> looking like a (-----------) (-------) indian file line; what type of carcinoma of the breast is this?

invasive lobular carcinoma

45

Peau d'orange is due to?

localized lymphedema due to a tumor of the breast

46

carcinome of the breast will spread fast/slow during pregnancy due to an increase of estrogen...

fast

47

of carcinoma of the breast is to spread by blood where will it go?

lung, bone, liver, adrenals