Breast Cancer Flashcards
(23 cards)
Most common cancer in females in uk
Breast cancer
Preg Woman presented with breast mass
- Refer to breast specialist
- Breast US
- Mamography + fetal shield
- Biopsy specimen not cytology
- Mets workup ( chest xray - liver US and Bone MRI if needed)
Lymph node assesment in breast cancer
- US
- Needle biopsy
IF +ve: axillary clearance
If -ve: sentinel node biopsy
What is the lifetime risk for a woman in the UK to develop breast cancer?
1 in 9
Which risk factor has the highest odds ratio for developing breast cancer?
being a female
What is the most common histopathological type of breast cancer?
invasive ductal carcinoma
What percentage of breast cancer cases during pregnancy are lymph node-positive?
2 in 3
Which chemotherapy regimen is considered safe for breast cancer during pregnancy, and when should it be initiated?
CAF
Cyclophophamide
Doxorubicin
Fluorouracil
from 14 weeks
Which treatment is acceptable in the first trimester for stage 1 and 2 breast cancer during pregnancy?
Surgery without reconstruction
When is it safe to start radiotherapy for stage 1 and 2 breast cancer during pregnancy?
after delivery
Which chemotherapy is preferred for lymph node-positive breast cancer?
Taxanes
Name two indications for chemotherapy in breast cancer.
- mass > 1cm
- LN +ve
What is the initial step in evaluating a pregnant woman with a breast mass?
refer to breast specialist
What is the first-line investigation for a pregnant woman with a breast mass?
Breast Ultrasound
How is axillary lymph node involvement initially assessed in breast cancer?
preoperative ultrasound & needle biopsy
What is included in the metastatic workup for breast cancer during pregnancy?
CXR
Liver US
(MRI selected bone)
How long after Tamoxifen treatment for breast cancer is it safe to conceive?
3 m
How long after chemotherapy treatment for breast cancer is it safe to conceive?
2 years
What is the UKMEC category for hormonal contraception in women with a past history of breast cancer?
3
What is the UKMEC category for hormonal contraception in women with a recent history of breast cancer?
4
What is the safest contraceptive method for women after breast cancer?
IUCD
When is breast reconstruction recommended for breast cancer during pregnancy?
after delivery
What is the lifetime risk of developing breast cancer for individuals with BRCA1 or BRCA2 mutations?
BRCA 1: 65%
BRCA 2: 45%
