Breast Cancer

Question 1

Among these, proliferative lesions (especially those with histologic atypia) are associated with an increased risk of breast cancer

Answer 1

benign breast disease

Question 2

T/F the more connective tissue a breast has, the more likely it will develop breast cancer

Answer 2

true

Question 3

consistently associated with a higher risk of breast cancer among postmenopausal women

Answer 3

A higher BMIand/orperimenopausal weight gain

Question 4

Type of work that is now recognized by WHO as a probable carcinogen

Answer 4

night shift work

Question 5

Contributors to cumulative lifetime exposure to estrogen

Answer 5

early menarche, late menopause, no breastfeeding, BC, postmenopausal hormone therapy

Question 6

inherited as autosomal dominant, highly penetrant, germline mutations that are associated with an inherited susceptibility to breast and ovarian cancer.

Answer 6

BRCA1 and BRCA2

Question 7

Women taller than what height have a higher risk of breast cancer?

Answer 7

> 175 cm

Question 8

Male risk factors for breast cancer

Answer 8

klinefelter’s, testicular/liver pathology, family h/o and BRCA2

Question 9

Recommended age group for annual mammograms

Answer 9

50-74

Question 10

Screening recommendations for women at high risk of breast cancer

Answer 10

Annual mammogram and MRI starting at age 25. Clinical breast exam every 3-6 months

Question 11

Recommendationg for annual breast exams

Answer 11

every 2-3 yrs from 20-39, then annually

Question 12

How long should you examine each breast?

Answer 12

3-5 minutes

Question 13

Percentage of breast cancers found on mammogram

Answer 13

80-90%

Question 14

Type of breast CA where neoplastic lesions confined to the breast ducts and lobules

Answer 14

Noninvasive (DCIS)

Question 15

affects 1 breast. will go on to develop a recurrence or an invasive ductal carcinoma within 10 years if they’ve only been treated with a limited biopsy

Answer 15

Ductal carcinoma in situ

Question 16

These lesions are most often identified on mammograms as clustered microcalcifications with or without a palpable mass

Answer 16

Ductal carcinoma in situ

Question 17

Tx of Ductal carcinoma in situ

Answer 17

breast conserving tx

Question 18

Invasive cancers can develop in either breast. will go on to develop invasive lobular carcinoma or invasive ductal carcinoma within 20 years if a limited biopsy was performed

Answer 18

Lobular carcinoma in situ (LCIS)‏

Question 19

Tx of Lobular carcinoma in situ (LCIS)‏

Answer 19

excisional biopsy or BCT

Question 20

never a palpable lesion and no characteristic mammographic appearance

Answer 20

Lobular carcinoma in situ (LCIS)‏

Question 21

Most common type of invasive breast cancer

Answer 21

Infiltrating ductal carcinomas 70-80%

Question 22

T/F All patients should undergo surgery following neoadjuvant systemic therapy, even if they have a complete clinicaland/orradiological response

Answer 22

true

Question 23

Name the two most rare invasive breast cancers

Answer 23

Paget’s Dz and infammatory breast CA

Question 24

Disorder of the nipple and areola. Eczematoid appearance w/ crusting, scaling and erosion. Breast cancer cells within the nipple and areolar epidermis

Answer 24

Paget’s Dz

Question 25

Always associated w/ underlying mammary carcinoma either in situ or invasive

Answer 25

Paget's Dz

Question 26

Rapidly progressive tumor w/ high chance for early metastases. Presentation includes: painful, tender, firm enlarged breast. Skin has peau d'orange appearance

Answer 26

inflammatory breast CA

Question 27

Removal of breast and associated lymph nodes

Answer 27

modified radical mastectomy

Question 28

selective estrogen receptor modulators (SERMS) that is beneficial in tumors that are ER/PR positive

Answer 28

tamoxifen

Question 29

Greatest risk for recurrence of breast cancer

Answer 29

within the first 5 yrs

Question 30

How often should a woman with h/o of breast cancer have a H&P and mammograms?

Answer 30

every 3-6 months first 3 years. Then every 6-12 months for 2 years. then annually