Calcium Channel Blocker Toxicity

Question 1

Pathphysiology of Calcium Channel blockers

Answer 1

1. CCB bind antagonistically to Voltage-gated calcium channels
2. inihibits calcium influx during phase 2 of cardiac cycle
3. Reduces Chronotropy, inotropy, dromotropy
4. Vasodilation
5. Impair insulin release
6. Bradycardia, Hypotension, heart blocks, Hyperglycaemia
7. Cardiogenic shock
8. MODS
9. Death

Question 2

What is the difference between Dihydropyridines and Non-dihydropyridines

Answer 2

Dihydropyridines - Act on Vascular smooth muscle

Non-dihydropyridines - Act on cardiac and vascular smooth muscle

Question 3

What are CCB used for?

Answer 3

• Hypertension
• Coronary artery disease

Question 4

What are some non-dihydripyridine

Answer 4

• Verapamil
• Diltiazem

Question 5

What are some Dihydropyridines?

Answer 5

• Amlodipine
• Felodipine
• Lercanidipine
• Nifedipine
• Nimodipine

Question 6

What is the management for CCB?

Answer 6

• 1L - 2L Fluid