Drug Induced hyperthermia

Question 1

What 8 Drugs are associated with Drug-induced Hyperthermia

Answer 1

1. Amphetamines
2. Cocaine
3. Lithium
4. MAO inhibitors
5. MDMA/Ecstasy
6. PCP
7. SSRis/SNRIs
8. Tramadol

Question 2

What is considered Moderate Drug-induced hyperthermia?

Answer 2

• Hyperthermia (38-39degrees)
• Altered Conscious state/agitation
• Tremor, increased muscle tone

Question 3

What is the management for Moderate Drug-induced hyperthermia

Answer 3

• MICA
• Sedate (midazolam)
• Cool
• Hydrate

Question 4

Pathophysiology of serotonin syndrome

Answer 4

1. Increased serotonin exposure
2. Excess serotonin in synaptic cleft
3. Overactivation of 5-HT receptors
4. CNS overstimulation (agitation, confusion, delirium)
5. Autonomic neervous system dysregulation
6. Hyperthermia, tachycardia, hypertension, diaphoresis
7. Increased metabolic activity
8. Heat dissipation failure
9. Cellular damage from hyperthermia
10. MODS
11. Death