Calcium, Magnesium, & Phosphorus pt. 2 Flashcards
(56 cards)
What are normal phosphorus levels
2.4 - 4.5 mg/dL
What is the % of phosphorus in the bone compared to the blood?
85% in bone & 1% in blood
What is the major role of phosphorus?
Bone formation
List 5 other functions of phosphorus
1) Needed to make ATP
2) Metabolism of glucose, fats, & proteins
3) Helps excrete H+ ions in acid-base balance
4) Body controls balance through absorption & excretion loop
5) get it from diet & excrete via urine
What is the difference between inorganic & organic phosphorus?
Inorganic → in the blood & what is measured
Organic → in the cells
Phosphorus levels considered hypophosphatemia
Less than 2.5 mg/dL → considered severe when < 1 mg/dL
List 8 causes of hypophosphatemia
1) Fluid shifts & losses thru kidneys
2) Prolonged antacid use
3) Corticosteroids, loop diuretics, increased Mg+ intake, excessive Alc intake, DKA
4) Increased glucose intake
5) TPN
6) Respiratory alkalosis
7) Low Vit. D levels
8) Malnourished or critically ill
How do antacids cause hypophosphatemia & list 2 examples
Bind w phosphorus & increase excretion through stool
1) Ca++ carbonate (tums)
2) Aluminum
How does increased glucose intake cause hypophosphatemia
Forces insulin & phosphorus out of the blood & into the cell
How does TPN cause hypophosphatemia
There is NOT enough phosphorus & can cause phosphorus to go into the muscle
List 6 Sx assoicated with hypophosphatemia
1) Decreased ATP production
2) Altered neural function
3) Altered musculoskeletal function
4) Blood disorder
5) Hypoxia to tissues
6) Mental fogginess, irritability
Hypophosphatemia:
What happens due to altered musculoskeletal function?
Muscles get weak → pt on a ventilator will not be able to wean off even if they need to
What is typical Tx for hypophosphatemia?
Oral supps → Potassium phosphate/ sodium phosphate (Neutra phos)
What is the typical dose of oral potassium supplements for hypophosphatemia?
250-500 mg several times a day (weight based)
Levels checked 2-12 hrs after giving
When might potassium supplements be given IV for hypophosphatemia?
Severe cases → usually under 1 mg/dL
Very irritating to the veins
Must be given slowly
Phosphorus levels considered hyperphosphatemia
levels exceed 4.5 mg/dL
Why does hyperphosphatemia occur?
Kidneys cannot excrete the phosphorus or extreme intake
What is the most common cause of hyperphosphatemia?
Renal dysfunction
List 2 other causes of hyperphosphatemia
1) Tissue injury → burns, heat stroke, low K+
2) Excess intake of phosphorus containing antacids & laxatives (help loosen stools)
What almost ALWAYS accompanies hyperphosphatemia?
Hypocalcemia
Clinical manifestations of hyperphosphatemia are related to ____
Hypocalcemia
List 4 clinical manifestations of hyperphosphatemia
1) Chvostek’s sign
2) Trousseau’s sign
3) Cardiac irritability
4) Neuromuscular irritability
List 3 things hyperphosphatemia can lead to
1) Bone disease
2) Hyperparathyroidism
3) Calcifications in tissues
List 3 Tx options for hyperphosphatemia
1) Treat the cause!!
2) Dialysis if needed
3) Avoid phosphorus high foods