Oxygen Flashcards
(71 cards)
Define ventilation
Gas distribution in and out of the pulmonary airways
What does ventilation assess the status of?
CO2
Define pulmonary perfusion
Blood flow from the right side of the heart, through the pulmonary circulation & into the left side of the heart
Define diffusion
Gas movement from an area of greater to lesser concentration through semipermeable membrane
Explain the receiving end & supplying end of blood in the alveoli & capillaries
Alveoli receive O2 at ~ 4L/min & capillaries supply blood at ~ 5L/min
What is the average VQ ratio?
4:5 or 0.8
What does VQ ratio look at?
Ventilation to perfusion ratio
What does VQ ratio depend on?
Body position & regions of the lung
Explain the difference of intrapleural pressure btwn the apex & base of the lung
Apex → more negative pressure
Base → less negative pressure
Explain the difference of transmural pressure gradient btwn apex & base of the lungs
Apex → greater
Base → smaller
Explain the difference btwn alveoli in the apex & base of the lungs
Apex → larger & less compliant
Base → smaller & more compliant
Explain the difference in ventilation btwn the apex & base of the lungs
Apex → less ventilation
Base → more ventilation
What does less compliant alveoli mean?
Means we just don’t get as good of ventilation at the top of our lungs
How can sitting up in bed affect ventilation?
Gets ventilation down to the base of the lungs
V/Q mismatch:
What is shunting? Hint: 3
1) Problem with decreased ventilation
2) Alveoli perfused but are not ventilated
3) Allows deoxygenated blood to go into left side of the heart & into the body
V/Q mismatch:
List 6 disorders associated with shunting
1) congenital
2) airway obstruction
3) ARDS
4) pneumonia
5) atelectasis
6) pulmonary edema
V/Q mismatch:
Describe dead space
When there is decreased perfusion (not enough) or a problem w blood in the lungs becoming oxygenated
V/Q mismatch:
List 2 disorders associated with dead space
1) Pulmonary embolism
2) Pulmonary infarction
V/Q mismatch:
Describe silent unit Hint: 2
1) Problem with ventilation & perfusion
2) There is shunting & dead space
V/Q mismatch:
List 2 disorders associated with silent unit
1) ARDS
2) Pneumothorax
Define hypoxemia
Low arterial oxygen tension in the blood
Adversely affects every tissue in the body
Explain the supply & demand mismatch of hypoxemia Hint: 2
1) Poor perfusion such as ischemia
2) Decreased arterial O2 such as anemia
What must be provided until cause of hypoxemia can be reversed?
Must provide oxygen
List 5 causes of hypoxemia
1) Depletion of ATP
2) Acidosis
3) Damage to cells from noxious stimuli (i.e. poison)
4) Abnormal Ca inside the cell
5) Inflammatory response