Cancer Flashcards Preview

Semester 4 (NME) > Cancer > Flashcards

Flashcards in Cancer Deck (12):
1

What is the function of p53?

Normally has 20min half life, but when cell is stressed it dissociates from MSM2 to:
Stop cell cycle (inhibits CDK's), promote DNA repair genes and causes increased BAX/BAK (pro-apoptosis)

2

What is the Rb protein?

Retinoblastoma (TSG) - Coded by RB1 gene
Stops G1 to S transition by inhibiting E2F transcription factors
Inactive (hyperphosphorylated) in dividing cells

3

What is RAS?

Proto-oncogene coded for by KRAS/H-RAS genes
GTPase which increases MAPkinase cascades to increases proliferation
Can be stuck in active form by single point mutation

4

What is MYc?

A transcription factor for cycle progression

5

What are telomeres?

Continually degrade each time a cell divides to limit it's lifespan
Telemerase protects the telomers, it's switched off in normal cells but on in tumour cells

6

What is B-Catenin?

Proto-oncogene which binds to TCF to up-regulate production of MYC and cyclin D1

7

What is the DCC gene?

Deleted in colorectal cancer gene
Partly tumour suppressor

8

What is the SRC family?

Family of tyrosine kinases which are proto-oncogenes

9

What is the role of tyrosine kinases in cells?

Promote survival/ angiogenesis/ proliferation and invasion

10

What effect does DNA methylation have on genes?

Stops gene transcription

11

What is the TNM staging?

Tumour (0-4), Nodes (0-3), Metastasis (0 or 1)
Combined to give TNM stage I to IV

12

What does Tx or Nx mean in the TNM staging?

Can't be evaluated