Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pathophysiology Spring 16 > Cancer > Flashcards

Cancer Flashcards

(48 cards)

Start Studying
1
Q

support cells in tissues, blood vessels, neurons, connective tissue

A

stromal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

specific/specialized cells to tissues ex cardiomyocyte

A

parenchymal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

cells derived from neural crest/mesenchyme

A

mesenchymal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cells that give rise to connective tissue

A

mesenchymal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

oma

A

benign tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

carcinoma

A

malignant tumor of EPITHELIAL origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

adenocarcinoma

A

Malignant tumor of GLANDULAR tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

sarcoma

A

malignant tumor of MESENCHYMAL origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

blastoma

A

malignant tumor of PRECURSOR cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

leukemia

lymphoma

mealnoma

A

all malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

looks like where it came from

A

well differentiated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

doesn’t look like any cell in the body

A

Undifferentiated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

well demarcated

A

benign, can see borders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

poorly demarcated

A

malignant, cannon differentiate borders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

locally invasis

A

malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

poorly differentiated

A

malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

initial carcinogenic induced mutation that gets everything started

daughter cells have same mutation, and they can pick up new mutations

A

Transformation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

mutated cells continue to grow and divide and continue to make more genetically mutated cells

A

progression and proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

has abnormal activity or is expressed at abnormal levels

A

oncogene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

people cannot be born with one ____________ but can be born with one ______________.

Study These Flashcards
A

mutant oncogene, mutant tumor supressor gene

21
Q

TUMOR SUPRESSOR or ONCOGENE:

Bcl-2 - b cell lymphoma

Study These Flashcards
A

ONCOGENE

b cell lymphoma

22
Q

TUMOR SUPRESSOR or ONCOGENE:

BRCA 1 and 2

Study These Flashcards
A

TUMOR SUPRESSOR

  • breast cancer
23
Q

TUMOR SUPRESSOR or ONCOGENE:

HER2 / NEU

Study These Flashcards
A

ONCOGENE

ovarian and breast cancer, ependymal growth factor

24
Q

TUMOR SUPRESSOR or ONCOGENE:

APC

Study These Flashcards
A

TUMOR SUPRESSOR

colorectal

25
TUMOR SUPRESSOR or ONCOGENE: RB1
TUMOR SUPRESSOR retinoblasotma
26
TUMOR SUPRESSOR or ONCOGENE: N- MYC
ONCOGENE: neuroblastoma
27
TUMOR SUPRESSOR or ONCOGENE: C-Myc
ONCOGENE: burkitt lymphoma and others
28
TUMOR SUPRESSOR or ONCOGENE: RAS
ONCOGENE 30 - 30% of all cancers
29
TUMOR SUPRESSOR or ONCOGENE: MSII
TUMOR SUPRESSOR colorectal/ endometrial, gastric
30
TUMOR SUPRESSOR or ONCOGENE: NF1 / NF2
TUMOR SUPRESSOR neuroblastoma
31
How does RAS transform from a proto-oncogen to an oncogene
loses its ability to convert GTP to GDP - RAS is now permanently on and the cell is SELF SUFFICIENT
32
Tow hit hypothesis applies to ________.
insensitivity of anti-growth signals example = RB- retinoblastoma gene
33
what gene is in charge of evading apoptosis
p53
34
when the p53 gene is mutated the cell cycle is never _______, so mutated cells continue to proliferate
stopped
35
limitless replicative potential
telomerase
36
sustained angiogenesis
VEGF
37
Cancer cells must exhibit __________. they have to chew through the ____________. Cancer cells use _____________ to get through the collagen of the membrane and secretes ____________ and attaches itself to ______________ to pull through the basement membrane.
contact inhibition basement membrane type IV collagenase proteolytic enzymes fibinolectin
38
E6 binds up
RB
39
E7 binds up
p53
40
disable proteins, but DO NOT effect the gene
E6 and E7
41
strains NOT covered by HPV vaccine that cause cervical cancer
35 and 31
42
strains covered by HPV vaccine that cause cervical cancer
16 and 18 cause 70% of cervical cancers
43
strainscovered by HPV vaccine that cause genital warts
6 and 11
44
chemotherapy targets
rapidly dividing cells
45
because all hematopoietic stem cells are effected by chemotherapy, we will see_________.
Anemia and Neutropenia
46
when does chemo brain stop?
when chemo stops - chemo actually doesn't have the ability to reach the CNS
47
______________ helps prevent resistant cells
Combination therapy
48
starvation due to nutrients going to cancer
cachexia

Pathophysiology Spring 16 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions