Cancer associations, paraneoplastic syndromes Flashcards Preview

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Flashcards in Cancer associations, paraneoplastic syndromes Deck (55):
1

CCl4

Centrilobular necrosis and fatty change of the liver

1

2nd leading cause of lung cancer

Radon

1

Antibodies against presynaptic Ca2+ channels

Lambert-Eaton

 

Small cell carcinoma

2

EPO production

2

HPV

Cervical and penile cancer (16,18)

Throat or head and neck cancer

3

HHV-8

Kaposi sarcoma, body cavity fluid B cell lymphoma

4

XP, albinism

Melanoma, BCC, and especially squamous cell carcinoma of the skin

6

Aromatic amides

Transitional cell carcinoma

6

Cigarette smoke: lung

Squamous and small cell

7

Down syndrome

ALL, AML

7

Hypercalcemia

Squamous cell carcinoma (PTHrp)

8

Vinyl chloride

Angiosarcoma of liver

9

Barret esophagus

Adenocarcinoma of esophagus

10

Arsenic

Liver: Angiosarcoma

Lung: Lung cancer

Skin: Squamous cell carcinoma

11

Cushing syndrome

Small cell lung cancer

 

Increased ACTH

12

Autoimmune diseases

Lymphoma

12

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

Gastric adenocarcinoma

13

HBV, HCV

HCC

15

Actinic keratosis

SCC of skin

16

Dermatomyositis

Lung cancer

16

Paget disease of bone

Secondary osteosarcoma and fibrosarcoma

17

Cigarette smoke: bladder

Transitional cell

17

Hypercalcemia

Lymphoma, usually Hodgkin's

 

Increased vitamin D

18

AIDS

Non-Hodgkins lymphoma, Kaposi sarcoma

19

Cigarette smoke: kidney

Renal cell carcinoma

21

Cirrhosis

HCC

23

UC

Colonic adenocarcinoma

24

MG, pure RBC aplasia

Thymoma

25

Cushing syndrome

Small cell lung cancer

26

Cigarette smoke: pancreas

Pancreatic adenocarcinoma

27

Ionizing radiation: thyroid

Papillary carcinoma of the thyroid

27

EBV

Burkitt lymphoma, nasopharyngeal carcinoma, CNS lymphoma, Hodgkin lymphoma

28

Where do alfatoxins come from?

Aspergillus

30

SIADH

Small cell lung cancer

32

Polycythemia

Renal cell carcinoma, HCC

34

Immunodeficiency states

Lymphomas

36

Asbestos

Bronchogenic carcinoma > mesothelioma

37

Dysplastic nevus

Melanoma

38

Radiation exposure

Leukemia, sarcoma, breast cancer, papillary thyroid cancer

38

Cigarette smoke: larynx

Squamous cell carcinoma

39

H. pylori

Gastric adenocarcinoma, MALToma

41

Radon

Lung cancer

42

PTHrP

Squamous cell carcinoma of the lung, renal cell carcinoma, breast cancer

 

Hypercalcemia

 

43

Lambert-Eaton syndrome

Small cell cancer

45

Acanthosis nigricans

Visceral malignancy, esp stomach

46

Plummer-Vinson syndrome

Squamous carcinoma of esophagus

 

(PVS = dysphagia + glossitis + iron-deficiency anemia)

47

Alkylating agents

Leukemias, lymphoma

48

Increased ADH

Small cell lung cancer or intracranial tumors

 

SIADH

49

Patient with MG has high hematocrit. Why?

Has a thymoma that's producing EPO

50

Tuberous sclerosis

Giant cell astrocytoma, renal cell angiomyolipoma, cardiac rhabdomyoma

51

Nitrosamines

Gastric cancer

52

Schistosoma haematobium

Squamous cell bladder cancer

53

Aflatoxin

HCC

54

HTLV-1

Adult T-cell lymphoma/leukemia

55

Cigarette smoke: esophagus

Squamous cell/adenocarcinoma