Cancer Case Study Flashcards
1
Q
Why is dexamethasone included in treatment of brain tumors?
A
- Corticosteroid - Immunosuppressants (decreases swelling, increases tight junctions, reconstitutes BBB –> dec. swelling)
- Antiemetic (decreases nausea/vomiting)
2
Q
What things about the tumor affect the outcome of chemotherapy treatment?
A
Stage, Location & Resistance (-innate -2 deg)
3
Q
What things about the patient affect the outcome of chemotherapy treatment?
A
- Family support
- Age of patient
- Overall Health - Karnofsky
- Liver Function
- Kidney Function
- Bone Marrow Capacity
4
Q
Vincristine
A
- Stops spindle formation
- Interrupts Mitosis
- CCS - M phase
5
Q
Paclitaxel
A
- Increases Spindle formation
- Interrupts Mitosis
- CCS - M phase
6
Q
Etoposide
A
- Topoisomerase II inhibitor
- Causes strand breaks
- Damages DNA
- CCS - S phase
7
Q
Doxorubicin
A
- Intercalates
- Damages DNA
- CCNS
8
Q
Cisplatin
A
- Cross-links
- Platinum
- Damages DNA
- CCNS
9
Q
BCNU (Carmustine)
A
- Cross-links
- Alkylates
- Damages DNA
- CCNS
10
Q
TMZ (temozolomide)
A
- Cross-links
- Alkylates
- Damages DNA
- CCNS
11
Q
Cyclophosphamide
A
- Cross-links
- Alkylates
- Damages DNA
- CCNS
12
Q
Busulfan
A
- Cross-links
- Alkylates
- Damages DNA
- CCNS
13
Q
Fludarabine
A
- Inhibits DNA synthesizing enzymes [Purines - prevents DNA synthesis]
- CCS - S phase
14
Q
Ara-C (Cytarabine)
A
- Inhibits DNA synthesizing enzymes
- Pyrimidines
- Prevents DNA synthesis
- CCS - S phase
15
Q
5-FU
A
-Inhibits nucleotide synthesis
[Pyrimidine - Prevents DNA synthesis]
-CCS - S phase
“FU is not so Pur”
