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Flashcards in cancer drugs Deck (16):
1

alkylates DNA, ADE: pulm fibrosis

Busulfan

2

fragments DNA, ADE: pulm fibrosis

bleomycin

3

Blocks purine synth, metabolized by xanthine oxidase

6-MP

4

nitrogen mustard, alkylates DNA (electrophile that binds DNA)

nitrosoureas

5

folic acid analog that inhibits dihydrofolate reductase

MTX

6

intercalates DNA, produces O2 free radicals, cardotoxic

doxorubicin daunorubicin

7

DNA alkylating agents used in brain cancer

nitrosoureas

8

applied topically for AKs and basal cell cancers

5 FU

9

tx for childhood tumors (ewing sarcoma, wilma tumor, rhabdomyosarcoma)

dactinomycin

10

ADE: hemorrhagic cystitis

cyclophosphamide, ifosfomide

11

crosslinks DNA, nephrotoxic and ototoxic

cysplatin

12

prevents tubulin disassembly

paclitaxel

13

inhibits ribonucleotide reductase

hyroxyurea

14

inhibitor of the mutated tyrosine kinase produced by the philadelphia chromosome

imatinib

15

monoclonal Ab against HER2

trastuzumab

16

SERM that does not increase the risk of endometrial cancer

raloxifene