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Flashcards in Cannabis Deck (18)
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1

Endocannabinoid system

affects pain modulation, memory, appetite, inflammatory + other responses

2

CB1

~ primarily found in brain + CNS
~ located at pre-synpase of glutamate + GABA neurotransmission
~ THC binds

3

THC

TetraHydroCannabinol

4

CB2

~ mostly found in organs associated w/ immune system
~ activation does not cause psychoactive effects like CB1
~ CBN binds

5

CBN

cannabinol

6

Anadamine

~ natural endocannabinoid that binds to brain cannabinoid receptors
~ not stored, synthesised when + where needed
~ binds to presynaptic CB1 = dopamine release in NAc

7

Low dose of anadamine

~ anxiolytic properties
~ relaxation + friendliness
~ impaired STM
~ loss of temporal awareness

8

High dose of anadamine

~ panic
~ toxic delirium
~ psychosis

9

Name locations where CB1 receptors are found.

~ hypothalamus (memory)
~ basal ganglia (movement)
~ cerebellum (movement)

10

CB1 activation causes...

decrease in Ach release

11

Acute toxic psychosis

ST: delirium w/ confusion, hallucinations, acute paranoid state
LT: schizophreniform psychosis, depression, depersonalisation

12

Cannabis + Schizophrenia

genetic disposition to schizophrenia associated with increase cannabis use

13

Cannabis + Addiction

~ 9% of users = abuse + dependence
~ 50% of users = impaired control over use
~ mesolimbic-dopamine pathway (increase of dopamine in NAc)

14

Cannabis Withdrawal

~ occurs in combo w/ decrease in mesolimbic-dopamine function
~ mild comp. other drugs
~ might contribute to cannabis dependence through -ve reinforcement

15

Cannabis Tolerance

~ chronic administration causes global down regulation in activity of cannabinoid receptors
~ lower dopamine release

16

Chronic users paradox

chronic users need less cannabis to get high

17

Possible explanations of chronic users paradox

1) users focus on the effects they want to achieve - novice users unable to appreciate effects
2) fat soluble nature of THC + its metabolites = stored in fast then released gradually = higher basal lvl than novice
3) Liver more efficient at metabolising THC = metabolites more quickly available

18

Symptoms of cannabis withdrawal

~ anxiety
~ weight/appetite loss
~ chills + shaking + sweating
~ depressed mood