Flashcards in Cannabis Deck (18)
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1
Endocannabinoid system
affects pain modulation, memory, appetite, inflammatory + other responses
2
CB1
~ primarily found in brain + CNS
~ located at pre-synpase of glutamate + GABA neurotransmission
~ THC binds
3
THC
TetraHydroCannabinol
4
CB2
~ mostly found in organs associated w/ immune system
~ activation does not cause psychoactive effects like CB1
~ CBN binds
5
CBN
cannabinol
6
Anadamine
~ natural endocannabinoid that binds to brain cannabinoid receptors
~ not stored, synthesised when + where needed
~ binds to presynaptic CB1 = dopamine release in NAc
7
Low dose of anadamine
~ anxiolytic properties
~ relaxation + friendliness
~ impaired STM
~ loss of temporal awareness
8
High dose of anadamine
~ panic
~ toxic delirium
~ psychosis
9
Name locations where CB1 receptors are found.
~ hypothalamus (memory)
~ basal ganglia (movement)
~ cerebellum (movement)
10
CB1 activation causes...
decrease in Ach release
11
Acute toxic psychosis
ST: delirium w/ confusion, hallucinations, acute paranoid state
LT: schizophreniform psychosis, depression, depersonalisation
12
Cannabis + Schizophrenia
genetic disposition to schizophrenia associated with increase cannabis use
13
Cannabis + Addiction
~ 9% of users = abuse + dependence
~ 50% of users = impaired control over use
~ mesolimbic-dopamine pathway (increase of dopamine in NAc)
14
Cannabis Withdrawal
~ occurs in combo w/ decrease in mesolimbic-dopamine function
~ mild comp. other drugs
~ might contribute to cannabis dependence through -ve reinforcement
15
Cannabis Tolerance
~ chronic administration causes global down regulation in activity of cannabinoid receptors
~ lower dopamine release
16
Chronic users paradox
chronic users need less cannabis to get high
17
Possible explanations of chronic users paradox
1) users focus on the effects they want to achieve - novice users unable to appreciate effects
2) fat soluble nature of THC + its metabolites = stored in fast then released gradually = higher basal lvl than novice
3) Liver more efficient at metabolising THC = metabolites more quickly available
18
