carbapenems

Question 1

can you use against MRSA

Answer 1

no not active against it

Question 1

what are they and what is their spectrum of activity

Answer 1

beta lactam abx
BS activity

Question 2

meropenem 1 interaction with this anti epileptic drug

Answer 2

decreases conc of valproate
avoid

Question 3

a patient has immediate hypersensitivity to penicillins. can you give a carbapenem

Answer 3

NO because it is a beta lactam abx, similar structure. avoid

Question 4

a patient has sensitivity to penicillin. can you give carbapenem

Answer 4

use with caution in pt with sensitivity to beta lactam abx, but AVOID in history of immediate hypersensitivity

Question 5

why is imipenem administered in combination with cilastatin?

Answer 5

imipenem is inactivated in the kidney by enzymatic activity
so it is given with cilastatin with is a specific enzyme inhibitor which blocks its renal metabolism

Question 6

which cabapenem must be given in combination with cilastatin because it is partially inactivated in the kidney (cilastatin is a specific enzyme inhibitor which blocks its renal metabolism)

Answer 6

imipenem

Question 7

which carbamapen has less azure inducing potential and therefore can be used to treat CNS infection

Answer 7

meropenem

Question 8

cautions of ertapenem and imipenem

Answer 8

CNS disorders - risk of seziures
epilepsy
elderly (ertapenem)

Question 9

3 interactions of imipenem

Answer 9

• ganciclovir & valganciclovir - these are predicted to increase risk of seizures when given with imipenem. AVOID
• imipenem decreases conc of valproate - avoid

Question 10

ertapenem and meropenem 1 interaction

Answer 10

valproate - these abx decrease the conc of valproate so avoid

Question 11

MOA of carbapenems

Answer 11

beta lactam abx
inhibits cross linking of peptidoglycan during cell wall synthesis