fungal infection

Question 1

what bodily systems does aspergillosis affect?

Answer 1

most commonly respiratory tract
invasive forms can affect heart, brain, skin

Question 2

1st line and alternatives for aspergillosis infection

Answer 2

1st line voriconazole
2nd line liposomal amphotericin B
caspofungin or itraconazole in pt who are refractory to, or intolerant of voriconazole and liposomal amphotericin B

Question 3

vaginal candidiasis can be treated with locally acting antifungals or with fluconazole given by mouth. for resistant organisms in adults, the following can be given by mouth

Answer 3

itraconazole

Question 4

what are the echinocandins?

Answer 4

end in -fungin e.g. caspofungin

Question 5

for invasive or disseminated candidiasis, the following anti fungal class can be given

Answer 5

echinocandin (-fungin)

Question 6

what is an alternative for invasive or disseminated Candida albicans infection in clinically stable pt who have not received an azole antifungal recently

Answer 6

fluconazole

Question 7

what should be considered for initial treatment of CNS candidiasis

Answer 7

amphotericin B

Question 8

what can you use for infections caused y fluconazole resistant Candida spp. when oral therapy is required, or in pt intolerant of amphotericin B or an echinocandin

Answer 8

voriconazole

Question 9

in refractory cases of invasive or disseminated candidiasis what can you give

Answer 9

flucytosine + IV amphotericin B