leprosy

Question 1

if a pt has leprosy, what should you do

Answer 1

must seek advice from a member of the Panel of Leprosy Opinion for treatment

Question 1

what bacteria is it caused by

Answer 1

Mycobacterium leprae

Question 2

what are the 3 drugs recommended

Answer 2

daprosone
rifampicin
clofazimine

Question 3

second line drugs that have significant activity against M. leprae (3)

Answer 3

ofloxacin
minocycline
clarithromycin
(2nd line because they are not as active as rifampicin)

Question 4

what regimen is recommended for Multibacilliary Leprosy?

Answer 4

3 drug regimen

Question 5

what regimen is recommended for paucibacillary leprosy?

Answer 5

2 drug regimen

Question 6

Paucilobacillary leprosy must be treated with a 2 drug regimen. what are the drugs and what is the duration they need to be taken for and what should you do if there is interruption

Answer 6

daprosone and rifampicin
6 months
if interrupted, recommence where it was left off to complete full course

Question 7

multibacillary leprosy must be treated with a 3 drug regimen. what are the drugs and how long do they need to be taken for

Answer 7

daprosone, rifampicin and clofazimine
at least 2 years
continue unchanged during both Type 1 (reversal) and Type 2 (erythema nodosum leprosum) reactions

Question 8

during type 1 reversal reactions in multibacillary leprosy, neuritic pain or weakness can herald the rapid onset of …
you need to intimate treatment with ….. straight away

Answer 8

permanent nerve damage
prednisolone

Question 9

mild type 2 reactions in multibacillary leprosy may respond to ..

Answer 9

aspirin

Question 10

severe type 2 reactions in multibacillary leprosy may require ….
the following unlicensed drug may also be useful in pt who have become CC dependent but should only be used under specialist supervision

Answer 10

CCs

thalidomide