Carcinogenesis Flashcards Preview

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Flashcards in Carcinogenesis Deck (26):
1

what is the source of aflatoxin and what is the associated cancer?

derived from aspergillus (improperly stored grains) and causes hepatocellular carcinoma

2

polycyclic hydrocarbons

source?
cancers?

cigarettes, smoked fish/meats

squamous cell or small cell carcinoma, urothelial carcinoma

3

b-napthylamine

source?
cancers?

dye or rubber

bladder cancer (urothelial)

4

mitrosamine

source?
cancers?

food preservatives

gastric carcinoma

5

asbestos

source?
cancers?

pipe fitters and ship builders

mesothelioma, lung cancer

6

vinyl chloride

source?
cancer?

plastics, PVC plastic for pipes

angiosarcoma of liver

7

chromium and nickel

bronchogenic carcinoma

8

arsenic

skin cancer

9

smoking

oral cavity, mid esophagus, larynx, lung cancers

10

alcohol

oropharynx, pancreatic an dhepatocellular carcinomas

11

Nickel

lung

12

radon

lung

13

Diethyl-Stilbesterol (DES

celar cell carcionooma of vagina

14

oral contraceptives

liver adenoma

15

UVB 280-320 aka UV radiation

formation of pyrimiddine dimers leads to DNA damage and NER damaged so you can get xerodermapigmentosa

16

atomic bomb will give you?

leukemias (but not CLL), thyroid cancer

17

CT scans in children give you?

leukemia and brain tumors

18

Hep B virus (HBV)

MOA
Cancer
Features

1) chronic inflammation with hepatocyte death producing genotoxic and mutagenic mediators
2) hepatocellular carcinoma
3) chronic liver cell injury and regenerative hyperplasia (cirrhosis)

19

EBV

MOA
Cancer
Features

1) polycolonal B cell rpofliferation increases risk of t(8:14) translocation
2) burkitt lymphoma, hodgkin, CNS B cell lymphoma in AIDS, Nasopharyngeal carcinoma

3) "starry sky appearance"

20

HPV

MOA
Cancer
Features

1) e6 inhibits P53, E7 inhibits RB
2) squamous cell carcinoma
3) low risk = 6 and 11
high risk = 16, 18, 31

21

HHV-8

MOA
Cancer
Features

1) infection of epithelial cells
2) kaposi sarcoma in AIDS
3) lesions filled with endothelial cells

22

HTLV-1

MOA
Cancer
Features

1) activation of TAX
2) T cell leukemia and lymphoma
3) Japan, Caribbean

23

Hep C

MOA
Cancer
Features

1) chronic liver cell injury, compensatory regeneration
2) hepatocellular carcinoma

24

HIV

MOA
Cancer
Features

1) polyclonal B cell activation to monoclonal B cell activation
2) primary CNS lymphoma, high grade B cell lymphoma

25

H. pylori

MOA
Cancer
Features

1) CagA
2)stomach cancer

26

shistosoma hematobium

squamous cell carcinoma or urinary bladder