Cardio: Antihyperlipidemic Drugs

Question 1

What are the PCSK9 Inhibitors?

Answer 1

O-Cum Antibodies

Question 2

What are the First drugs of choice to reduce blood-lipid levels? In what order to you give them?

Answer 2

• Statins
• Least potent first then go down the line
  
  • Simvastatin is least potent so you start them there.
  • Pravastatin is MOST potent.

Question 3

What are the fibrates?

Answer 3

Question 4

How do fibrates work? (MOA)

What are they used for?

Answer 4

Question 5

What are the lipid effects of Niacin?

Answer 5

Question 6

Which statins are metabolized by CYP450, 2C9?

Answer 6

fluvastatin

Question 7

What are the Lipid effects of statins?

Answer 7

Question 8

What is Niacin used for?

Answer 8

Question 9

For PCSK9 Inhibitors, list the

• Lipid Effects
• PKs
• ADRs

Answer 9

Question 10

What are the Bile-Acid Sequestrants (BAS)?

Answer 10

Question 11

What are the ADRs and DDIs for Bile-Acid Sequestrants (BAS)? What do you need to monitor because of the ADRs and DDIs?

Answer 11

Need to stagger doses throughout the day of other oral drugs because of DDIs

Question 12

What are the PCSK9 Inhibitors ?

Answer 12

O-Cum antibodies

Question 13

How Bile-Acid Sequestrants (BAS) work?

What condition are they especially food for?

Answer 13

• They force bile salts into the excretory pathway. The liver uses cholesterol to make bile salts, so these drugs decrease LDL by increasing cholesterol conversion into bile salts

Question 14

Statins have Extensive first-pass metabolism. How do you get around this?

Answer 14

Prodrugs (Simvastatin and Lovastatin)

Question 15

What is the MOA for statins?

Answer 15

Question 16

• For Omacor
  
  • What are its components?
  • What are its effects on lipids?
  • When do you use it?
  • What its PKs?

Answer 16

Question 17

What are they DDIs for fibrates?

Answer 17

Question 18

What is the channel that Ezetimibe actually blocks?

Answer 18

Question 19

What are the Bile-Acid Sequestrants drugs?

Answer 19

COLE-

Question 20

• What are the ADRs subsequent monitoring parameters for Niacin?
• What conditions are contraindicated for Niacine use?

Answer 20

Question 21

?Which statins are metabolized by CYP450, 3A4?

Answer 21

SAL

Question 22

Why do you give some statins at night? What are the statins that this is important to remember?

Answer 22

Question 23

What are the statins we need to remember?

Answer 23

My sim got the flu, so I gave them love and roses.

Question 24

What are the Fibrates?

Answer 24

A feminine gemini

Question 25

How do PCSK9 Inhibitors work?

Answer 25

Question 26

How does Niacin work, and what are the PKs for it? When do you use niacin for hyperlipidemia?

Answer 26

Decrease of hormone-sensitive lipase in adipose tissue

Question 27

For Ezetimibe, what is the MOA and what are the lipid effects?

Answer 27

Question 28

What are the components of Omega-3 Fatty Acids? What is the name of OTC drug?

Answer 28

Question 29

What are the ADRs for statins?

Answer 29

Question 30

What is Ezetimibe used for, and what is are its DDIs/ADRs?

Answer 30

Question 31

For fibrates, * What are the Laboratory test reactions? * What are the ADRs? * What are the Monitoring Parameters?

Answer 31

Question 32

How do you take Bile-Acid Sequestrants (BAS) and what are the lipid effects? What drugs do they have synergistic effects with?

Answer 32