Cardio part 2 Flashcards
(123 cards)
Where do acute MI’s usually begin?
Subendocardial layer, then progress outward w/ continued ischemia
Zone of ischemia
Tissue is O2 deprived but not injured
Zone of injury
Tissue is damaged, but not dead
Zone of necrosis
Death of myocardial tissue
25% of all MIs and highest mortality rate
LAD anterior wall of LV
-Increased risk of heart failure and dysrhythmias
MI with increased risk of sinus dysrhythmias
LCX posterior wall of LV
-Due to SA and AV node perfusion
17% of MIs, second highest mortality
RCA or LCX inferior wall of LV
-Mitral dysfunction of papillary muscles and chordae tendinae
STEMI
ST elevation MI
- Happening in real time, haven’t completed the infarct, still happening so you can still do something about it
- Abrupt occlusion
- More damage
NSTEMI
NonST elevation MI
- Partial or temp occlusion
- Ruptured plaque
What is a STEMI treated with?
PCI (percutaneous coronary intervention)
-Fibrinolytics (anticoagulant, clot buster)
What is a NSTEMI treated with?
Antiplatelets (aspirin, plavix)
Why does NSTEMI cause less damage than STEMI?
More ongoing process, body has time to generate collateral circulation
Leukocytosis with MI
Elevated WBC, usually 10-20,000
Cardiac enzymes with MI
CK-MB peak in 12-24 hrs, normal 48-72 hrs
Hallmark changes with AMI
- Myocardial ischemia
- Myocardial injury
- Myocardial infarction
- usually show no immediate ECG changes
Troponin 1 and T
Myocardial muscle protein, elevated 4-6 hrs after AMI, peaks 10-24 hrs, and remains for 5-7 days
Myocardial ischemia
T wave inversion, peaked T waves, ST segment depression (1 mm or one small box)
Myocardial injury
ST segment elevation in leads facing affected area show > or = 1 mm above baseline
Myocardial infarction
Q waves (pathologic) either >25% of the QRS complex height or >1mm wide
ACC goal for AMIs
Time from admit to ER to PCI should be less than 90 minutes
What is the recommended mode of treatment when PCI cannot be performed within 90 mins?
Fibrinolysis
Absolute contraindications for fibrinolysis
- Intracranial hemorrhage
- Known intracranial malignancy
- Known AV malformation
- Ischemic stroke within past 3 months
- Aortic dissection
- Active bleeding
- Closed head injury
Relative contraindications for fibrinolysis
- Uncontrolled HTN
- Active PUD (GI bleed)
- Recent surgery/trauma
- Pregnancy
- Concurrent anticoagulant use
Fibrinolytic meds
- Altepase (tPA)
- bolus then infusion - Streptokinase
- infusion
- can only be used once bc body develops antibodies, they’ll go into anaphylactic shock
- allergic reactions