cardiology Flashcards

(64 cards)

1
Q

Most efficient extractor of oxygen

A

heart

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2
Q

Intracellular junctions responsible for the cardiac syncytium

A

Gap junctions

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3
Q

Substance that dilates upstream blood vessels

A

Endothelium-derived Relaxing factor (EDRF) aka Nitric Oxide (NO)

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4
Q

Most potent vasoconstrictor

A

ADH (can incrase levels of endothelin 1)

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5
Q

An increase in Venous return will increase the stroke voluume, Basisl Stretching of cardiac sarcomeres will increase contraction

A

Frank-Starling Mechanism

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6
Q

Hypertension, irregular respiration and bradycardia due to activation of the CNS ischemic response and baroreceptor reflex in increased intracranial pressure

A

Cushing Reflex

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7
Q

Formula for BP based on Ohm’s Law

A
BP = CO x TPR
TPR= (HR x SV) x TPR

TPR is synonymous with systemic Vascular resistance and increases when arterioles vasoconstricted

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8
Q

Normal pressure at various parts of the adult circulation

A
Large Arteries = <120/80 mmHg
Systemic Capillaries: 17 mmHg
Vena Cava : 0 mmHg
Pulmonary Artery: 25/8 mmHg
Pulmonary Capillaries: 7 mmHg
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9
Q

Abdominojugular Reflux

A

At least 10 second pressure over the RUQ

(+) = sustained rise of >3 cm in JVP for at least 10-15 seconds after release of the hand

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10
Q

Pansystolic murmur of tricuspid regurgitation

Louder during inspiration and diminishes during forced expiration

A

Carvallo’s sign

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11
Q

High pitched, diastolic, decresendo blowing murur along the left sternal border due to dilation of the pulmonary valve ringl occurs in mitral valve disease and severe pulmonary hypertension

A

Graham Steell Murmur

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12
Q

Condition where the murmur of AS may be transmitted downward and to the apex and may be confused with the systolic murmur of mitral regurgitation

A

Gallavardin effect

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13
Q

Apical pulse is reduced and may retract in systole in constrictve pericarditis

A

Broadbent’s sign

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14
Q

A rapidly rising “water-hammer: pulse that collapses suddenly as arterial pressure falls rapidly during late systole and diastole, Seen in AR

A

Corrigan’s pulse

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15
Q

Capillary pulsation manifests as alternate flushing and paling of the skin while pressure is applied to the tip of the nail, seen in AR

A

Quincke’s pulse

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16
Q

A booming “pistol-shot” sound heard over the femoral arteries, seen in AR

A

Traube’s sign

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17
Q

To- and -fro murmur audible if the femoral artery is lightly compressed with a stethoscope, seen in AR

A

Duroziez Sign

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18
Q

Major noninvasive marker of increased CV morbidity/Mortality risk

A

LVH

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19
Q

Cornerstone in the diagnosis of acute and chronic ischemic Heart disease

A

ECG

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20
Q

ideal imaging modality for cardiac emergencies

A

2D echo

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21
Q

Gold standard for assessing LV mass and volumes

A

MRI

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22
Q

Triad of ruptured aneurysm

A

Left Flanked pain
hypotension
Pulsatile mass

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23
Q

Dx triad of Wolff-parkinson-white ECG pattern

A

wide QRS complex
Relatively short PR interval
Slurring of the initial part of the QRS complex (delta wave)

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24
Q

Triad of Chronic renal failure in ECG

A

Peaked T waves (hyperkalemia)
Long QT due to ST segment lengthening (hypocalcemia)
LVH (systemic hypertension)

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25
3 principal features of tamponade (BECK's TRIAD)
Hypotension Soft/Absent heart sound Jugular venous distension with a prominent x-descent but an absent y-descent
26
Plaques that have caused fatal thromboses tend to have......
Thin fibrous caps Relatively large lipid cores High content of macrophages
27
Major determinants of myocardial O2 demand
Heart rate Myocardial contractility Myocardial wall tension (stress)
28
triad of Buerger's disease
Claudication of the affected extreminity Raynaud's phenomenon Migratory superficial vein thrombophlebitis
29
Virchow's triad
Stasis Vascular/Endothelial damage Hypercoaguability
30
Dressler's triad (post-MI pericarditis)
fever pleuritic pain pericardial effusion
31
Drugs that increasses contractility
Digoxin Dobutamine Mlrinone
32
Drugs that reduces Preload
Diuretics Vasodilators ACE inhibitors, ARBS
33
Drugs that reduces afterload
Diuretics Vasodilators Ace inhibitors, ARBS Beta Blockers
34
Class IA drug
MOA: Binds to activated sodium channels and blocks the flow of sodium ions into the cardiac myocyte (PROLONGS AP) Clinical Use: Afib, Aflutter, VTach Examples: Quinidine, Procainamide, Disopyramide
35
Class IB drug
MOA: Binds to both activated and inactivated sodium channels and blocks the flow of sodium ions in the cardiac myocyte (SHORTENS AP) Clinical Use: Post ischemic arrythmia, V.Fib,V-tach Examples: Lidocaine, Tocainamide, Mexiletene
36
Class IC drug
MOA: Binds to activated sodium channels and blocks the flow of sodium ions into the cardiac myocyte (NO EFFECT on AP) Clinical use: Treatment of severe refractory Ventricular arrythia Examples: Flecainide, Encainide, Propafenone
37
Class II drugs
MOA: Blocks beta-adrenergic receptors Clinical use: Numerous Examples: Propanolol, metoprolol
38
Class III drugs
MOA: Binds potassium channels and blocks the flow of K in the myocyte (PROLONGS AP) Clinical use: Atrial and ventricular arrythmias Examples: Sotalol, Ibutilide, Bretylium, Amiodarone
39
Class IV drugs
MOA: Blocks voltage-gated calcium channels therbey blocking the flow of calcium into the cells Clnical use: Supraventricular tachycardia rate reduction in patients with Afib
40
[Antihypertensive Drug] that causes Na excretion and reduction in blood volume
diuretics
41
[Antihypertensive Drug] Calcium channel blocker that exerts more effect on the vessels than the heart
dihydropyridines | nifedipine, felodipine, amlodipine
42
[Antihypertensive Drug] Calcium channel blocker that exerts more effect on heart than the vessels
Nondihydropyridines | verapamil, Diltiaem
43
[Antihypertensive Drug] Decreases the work load of the hear
Beta blockers
44
[Antihypertensive Drug] Blocks the AT1 receptor of angiotensin II
ARBs
45
[Antihypertensive Drug] Notorious for drug-induced cough by increasing bradykinins
ACE inhibitors
46
[Antihypertensive Drug] Blocks aldosterone action in the collecting tubules
Spironolactone, Eplerenone
47
[Antihypertensive Drug] Hypertension with benign prostatic hyperplasia
alpha-1 anatagonists (Prasozin)
48
[Antihypertensive Drug] Maintenance medication for pre eclampsia
methyldopa
49
Physiologic basis for normal ECG tracing
P wave: atrial depolarization QRS complex: ventricular depolarization T wave: ventricular repolarization
50
Master pacemaker of the heart
SA node
51
Causes of depolarization of the SA node
Calcium influx (sodium influx will merely bring potential closer to threshold; however sodium is still the determinant of heart rate)
52
Chronotropic Incompetence
Failure to increase heart rate during exercise, alternatively defined as: 1) Unable to achieve 85% of predicted maximal heart rate 2) Unable to achieve a heart rate >100 bpm with exercise Maximal HR with exercise <2 SD below that of the age -matched control population
53
The only electrical connection between the atria and ventricles
AV node
54
Most common arrythmia mechanism
Reentry
55
Only reliable therapy for symptomatic bradycardia in the absence of extrinsic and reversible etiologies
Permanent pacemaking
56
Most rapid conduction in the heart
His bundle and bundle branchers
57
Most expeditious technique in the manangement of AV conduction block
transcutaneous pacing
58
Most common arrythmia identified during extended ECG monitoring
Atrial premature complexes
59
Most common sustained arrythmia
Atrial fibrillation
60
Has prolongation of PR befored dropped QRS complex
Mobitz type I
61
Has no prolangation of PR interval befored dropped QRS complex
Mobitz type II
62
Duration that distinguishes sustained from nonsustained ventricular tachycardia
>30 seconds
63
Most common arrythmia post-MI
Premature Ventricular Contraction
64
Most common lethal arrythmia post MI
Ventricular Fibrillation