CARDIORESPIRATORY Flashcards

(77 cards)

1
Q

What is a patient pathway?

A

A coordinated and structured plan of care that outlines the expected sequence of events, actions and interventions for patients with a specific health condition

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2
Q

What is the patient pathway for an acute MI?

A

Symptoms onset
Presentation to A&E or GO
History, examination, vital obs and ECG
Bloods
CXR
Diagnosis of UA/NSTEMI/STEMI
Initial management to stabilise pt and relieve symptoms
Repulsion therapy - Coronary angiogram and PCI or thrombolysis decision
Pharmacology management post-treatment e.g. bb, ACEi and statins as well as lifestyle changes
Ward care
Outpatient care with follow up included rehabilitation programmes e.g. supervise exercise

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3
Q

What are Zola’s triggers to health-seeking?

A

Interference with work or physical activity
Interferes with social relations
Assigning an arbitrary time limit
Interpersonal crisis e.g. a death
Sanctioning (others telling them to seek help)

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4
Q

What are barriers to rapid diagnosis of MI?

A

The ‘wait and see’ approach to chest pain
Attendance to GP and not immediately going to A&E
Misinterpretation of ECG
Troponin levels may not rise until up to 12 hours after symptom onset
Atypical presentation particularly women and diabetics
Long wait times
Communication barriers

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5
Q

What are some methods to reduce the delay in treatment of suspected acute coronary syndrome?

A

Increased public knowledge of symptoms and advice to seek medical attention immediately
NICE guidelines follow for early diagnosis
Fast-tracking admitting system in A+E
Rapid response ambulances that can provide early ECG and administer appropriate meds e.g. nitrates
Quality improvement initiatives

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6
Q

What are the benefits of publicly available performance indicators e.g. mortality following cardiac surgery?

A

Provide stats about healthcare providers
Informs pt and encourages choice
Transparency, honesty and being open which increases trust in health providers as a result
May identify outliers - can learn from hospitals with lower mortality rates
Standardises care
Regulatory compliance - GMC requires these to be reported
Clear numerical figure

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7
Q

What are the issues with using publicly available performance indicators such as mortality following cardiac surgery?

A

Risk of over-reliance on performance indicators which may cause providers to feel pressured to prioritise performance targets over other aspects of patient care (stops individualised patient care)
They provide a snapshot of care quality but may not capture the full picture e.g. pt experience
They rely on accurate and complete data collection and reporting but they may be errors or biases
There will always be random variation in mortality rates across hospitals
Must be adjusted for confounders
Incentivising targets may be a pervert practice i..e people avoid complex cases which could increase standardised mortality ratio
May be interpreted wrong by patients

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8
Q

What are the ethnic and gender differences in ischaemic heart disease?

A

Incidence increases with age
More common in males
Link to FHx and social disadvantages

Black Africans, African Caribbeans and South Asians in the UK are at higher risk of developing high blood pressure or type 2 diabetes compared with White Europeans

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9
Q

What causes the ethnic and gender differences in health and healthcare in IHD?

A

Different access to healthcare
Differences in health seeking behaviours
Inaccessibility due to language barrier
Genetic susceptibility
Discrimination
Increased smoking prevalence in ethnic minority populations
Oestrogen may have a protective effect against IHD
Risk of type 2 diabetes is roughly double for people with South Asian and African Caribbean background

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10
Q

What was the SABRE study?

A

Southall and Brent REvisited - a large long term epidemiological study investigating the social, environmental and genetic determinants of health and disease in a multi-ethnic population in the UK.
The aim is to identify the risk factors associated with CVD, t2 diabetes and other chronic disease in different ethnic groups and investigate how genetic, environmental and lifestyle factors interact to influence disease

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11
Q

How are ethnic and gender differences in IHD changing overtime?

A

Incidence of IHD is increasing in South Asians and Black Africans
The gender gap is narrowing

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12
Q

What are the major risk factors contributing to the incidence of CVD?

A

Hypertension
Smoking
DM
Hypercholesterolaemia
Obesity
Age
FHx
Male
Ethnicity - South Asian or Black African
Social deprivation
Lack of exercise
Heavy alcohol consumption

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13
Q

Are the major risk factors contributing to the incidence of CVD changing over time?

A

Smoking is decreasing overall but higher in teenage females
Diet is poor and obesity levels are rising rapidly
Diabetes mellitus prevalence is rapidly increasing
Physical activity is decreasing
Cholesterol levels and hypertension are decreasing due to better treatment
Deprivation is generally decreasing

Overall these changes are decreasing the rates of CHD death

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14
Q

How can an individuals absolute risk of CVD be estimated?

A

Framingham risk score
QRISK
Reynolds risk score
ASCVD risk estimator

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15
Q

What is the Framingham risk score?

A

estimates the 10-year risk of developing CVD. It was developed based on data from the Framingham Heart Study and includes age, sex, blood pressure, total cholesterol, HDL cholesterol, smoking status, and diabetes status as risk factors.

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16
Q

What is QRISK?

A

This is a newer risk prediction tool developed in the UK that estimates the 10-year risk of developing CVD. It includes additional risk factors such as ethnicity, body mass index (BMI), and family history of CVD.

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17
Q

Discuss the evidence associating lifestyle change with CVD risk

A

Cardioprotective diet - Mediterranean-style diet or DASH diet
Physical activity - at least 150 minutes of moderate intensity aerobic activity or 75 minutes of vigorough intensity aerobic activity
Smoking cessation
Weight management - overweight or obese have a 32% increased risk
Stress management
Alcohol cessation

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18
Q

What can doctors do to help patients make healthy lifestyle changes in regards to CVD?

A

Provide education
Set realistic and achievable goals
Provide resources e.g. smoking cessation help, exercise programmes,
Monitor progress
Collaborate with other HCP e.g. dieticians
Provide encouragement and motivation

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19
Q

Outline the benefits of smoking cessation on CV health

A

After 15 years stopping, the risk of MI falls to the same level as someone who has never smoked. The risk falls sharply 1-2 years after cessation ans then declines more slowly after that
Stopping smoking reduces the development of atherosclerosis
If you already have CHD, stoping smoking reduces the risk of all-cause mortality. And reduces the risk or new/recurrent cardiac events

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20
Q

What is primary prevention?

A

Prevention of a disease before its onset

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21
Q

What is secondary prevention?

A

Preventing progression or any adverse events once disease has developed

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22
Q

What is tertiary prevention?

A

Limiting the impact that an adverse event has on health

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23
Q

What are examples of primary, secondary and tertiary prevention in CVD?

A

Primary - smoking cessation, healthy eating, exercise
Secondary - antiplatelets, statins, antihypertensives
Tertiary - CABG, PCI, thrombolysis

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24
Q

What are the 2 strategies for preventing and managing diseases?

A

High risk strategy - identifies and targets individuals who are at high risk of developing a particular disease e.g. targeting those with hypercholesterolaemia and providing medication to reduce the risk of CVD

Population strategy - aims to reduce the incidence of a disease across the entire population by implementing broad=based intervention e.g. public health campaigns to encourage health eating

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25
What are the advantages/disadvantages of the ‘high-risk’ approach to preventing and managing diseases?
More effective in preventing disease amongst those most vulnerable Personalised interventions Cost-effective Less effective at reducing overall disease burden in the population May miss individuals at risk - may not identify everyone as ‘high risk’ Stigmatisation caused by targeting individuals at high risk Limited impact as only target a small popualtion
26
What are the advantages/disadvantages of the ‘population’ approach to preventing and managing diseases?
More cost effective and have the potential to impact a larger proportion of the population Reduces health disparities - does not target populations More sustainable as often involve changes in policy, environment or social norms which can have a lasting impact on health Broader impact which reduces overall incidence Less effecting at preventing disease in high-risk individuals Less personalised Limited effectiveness on high risk populations Costly
27
What is the prevention paradox?
A preventative measure that brings large benefits to the community offers little to each participating individual
28
How are risk tables generated?
Researchers collect data from a large population of those at risk of developing CVD and then use statistical models to identify which risk factors are most strongly associated with the development of the disease They then develop a mathematical model that combines these risk factors to predict an individuals risk of developing the disease over a certain time period These can be used to inform clinical decision making
29
Outline a strategy to reduce CVD in the local community?
Community based activities - exercise groups, healthy cooking classes, regular BP and cholesterol screenings CVD education Annual QRISK2 scores Educating members of the public at a younger age to instil healthy lifestyle habits e,g. Physical activity in schools Prescribing atorvastatin when a QRISK score is >10%
30
Whats the issue with hypertension?
It increases your risk of: CVD ACS CVA Cardiac failure PAD Aortic aneurysms Kidney disease Vascular depentia
31
What are the target blood pressures?
<80 Clinic <140/90 ABPM/HBPM <135/85 >80 Clinic <150/90 ABPM/HBPM <145/85
32
Outline lifestyle advice for managing hypertension?
<6g a day salt (ideally <3g) Reduce caffeine intake Stop smoking Drink less alcohol Balanced diet rich in fruit and vegetables Exercise more Lose weight
33
Outline the major precipitates of asthmatic attacks?
Infections Pollen, dust mites, animal fur, feathers Smoke, flumes, pollution Medicines e.g. aspirin Emotions - stress/laughter Sudden changes in temp, cold air, wind, humidity Mould or damp Exercise Cleaning and disinfectants Occupational allergens - bakers, farmers, carpenters, manufacturing plastics/foams/glues
34
What is the “hygeien hypothesis’ for asthma?
Glowing up in a ‘clean’ environment makes atopy more likely as immune system recognises inert particles as allergens
35
What are the risk factors for DVT?
History of DVT Cancer >60 Being overweight Male HF Medical illness e.g. acute infection Thrombophilias Inflammatory disorders e.g. vasculitis or IBD Varicose veins Smoking Recent major surgery Recent hospitalisation Recent trauma Chemotherapy Significant immobility Prolonged travel >4 hours Significant trauma or direct trauma to vein Hormone treatment - HRT or COCP Pregnancy and post partum Dehydration
36
who needs DVT prophylaxis?
All pt undergoing major surgery All pt admitted to hopsital with an acute medical illness and 1 or more additional risk factors Pt with stroke Pt with spinal cord injury
37
What preventative measures can be done for DVT?
Pharmacological prophylaxis with LMWH, fondaparinux or unfractionated heparin Mechanical prophylaxis - compression stockings, intermittent pneumatic compression devices Early mobilisation Avoid dehydration IVC filters in high risk!
38
What are some approaches to control the spread of TB?
Immunisation Contact tracing Chemoprophylaxis Screening Completion and compliance wit treatment Hygeiene
39
Outline the role of immunisation and contact tracing in TB control in the UK?
BCG vaccine is offered to anyone at risk e.g. healthcare workers, FHx of TB or living in an area where TB prevalence is high. It’s given from birth in countries where Tb is prevalence. Note its only given to those who are tuberculin negative (Mantoux test) When someone is diagnosed with TB, public health officials conduct a contact tracing investigation to identify people who may have been exposed to the infected individual - they can then be tested and if necessary, treated. This is vital as it helps identify individuals affected at an early stage which would otherwise be difficult as TB can lie latent
40
What is chemoprophylaxis for TB?
The use of antibiotics to prevent the development of active TB in people who have been exposed to the bacteria or have latent TB Treatment is with 6 months of isoniazid alone or 3 months of isioniazid and rifampicin
41
Who is screened for TB in the UK?
People who have been in close contact with someone who has active TB disease. People who have recently arrived in the UK from a country with a high incidence of TB. People who work or live in environments where TB is more common, such as healthcare workers and prison staff. People with certain medical conditions that increase their risk of developing TB, such as HIV infection or other conditions that weaken the immune system. People who misuse drugs or alcohol, or are homeless.
42
What are the approaches for limiting the impact of drug resistant TB?
Earlyt detection to prevent its spread - through targeted screening and contact tracing Effective treatment Infection control measures to prevent spread Continued research and development
43
Why do the priorities for TB control vary internationally?
Prevalence of TB Burden of drug-resistant TB Availability of resources to control it Effectiveness of existing TB control programs
44
Outline the epidemiology of lung cancer UK?
>43,000 case diagnosed each year 3rd most common cancer in the UK overall Incidence is highest in ages 85-89 Over the last decade, lung cancer incidence rates have remained stable Incidence rates are lower in Asian and Black ethnic groups and in people of mixed/multiple ethnicity Most common cause of cancer death 9/10 cases occur in people >60 79% of cases are preventable
45
What are the risk factors for lung cancer?
Cigarette smoking Radon Asbestosis Other occupational exposures - Arsenic, chromium, nickel, beryllium silica FHx Environmental air pollution Pulmonary scarring Previous radiation to chest Pulmonary fibrosis Chroni infections e.g HIV or TB
46
Outline the benefits of smoking cessation?
20 mins - pulse returns to normal 8 hours - nicotine levels reduced by 90%, CO levels reduced by 75% and oxygen levels return to normal which improves circulation 24 hours - CO and nicotine are eliminated from the body and the lungs start to clear out smoking debris 48 hours - all traces of nicotine are removed from the body 72 hours - breathing is easier as bronchial relax and energy levels will increase 2-12 weeks - circulation improves 1 month - physical appearance improves due to improved skin perfusion 3-9 months - cough and wheeze declines 1 year - the excess risk of MI reduces by half 10 years - risk of lung cancer falls to about half of that of a continuing smoker 15 years - risk of MI falls to same level as someone who never smoked Others - teeth improve, no stress about second hand smoke, home smells better, reduced risk of fire, financial and time
47
What are some campgains to stop smoking?
Education in school and to pt Tobacco TV and adverts banned Taxes higher Adverts on cigarette packs about risk Age restriction Smoking banned in public enclosed places Mass-media campaigns about benefits Wider access to smoking cessation services
48
What % of smoker quit each year? How does smoking affect your life expectancy?
Only 2-3% of smokers stop each year because of how addictive nicotine is For every year smoking persists >40, life expectancy decreases by 3 months Life expectancy for smokers is at least 10 years shorter than for nonsmokers. Quitting smoking before the age of 40 reduces the risk of dying from smoking-related disease by about 90%.
49
Outline the stages of change model?
Precontemplation Contemplation Determination Action Relapse Mainatnence
50
How can you convince an unwilling patient to quit smoking?
5 Rs Relevance - why is it important? (2nd hand exposure, health, finances) Risks - remind them of negative impacts Rewards - benefits such as finance, improves mortality, regaining taste Roadblocks - identify what is stopping them Repetition - every time you see them release this
51
How can you convince an willing patient to quit smoking?
5 As - Ask to quit at every visit - Advise to quit - Assess willingness to quit - Assist quitting with pharmacotherapy and counselling - Arrange follow up
52
What are the main job causes of occupational lung disease?
asbestosis - roofers, plumbers Coal - miners Aspergillosis - malt worker or farmer Cigarette smoke Radiation - radiographer Silica - metal, pottery Arsenic - paint factory
53
What is Industrial injuries Disablement benefit?
for people who are disabled because of an accident at work, or who have certain diseases caused by their work
54
Whats the role of the doctor when seeing occupational lung disease?
Notify public health authority
55
Who should not recieve the BCG vaccine?
Immuncompromised Pregnant women Anyone who has already had TB or the vaccine i.e. tuberculin positive
56
Why is the BCG vaccine so essential for TB prevention?
It increases herd immunity which will decrease population prevalence
57
What is an epidemic?
a widespread occurrence of an infectious disease in a community at a particular time.
58
What is an endemic?
when that infection is constantly present, or maintained at a baseline level
59
What is a pandemic?
a widespread occurrence of an infectious disease over a whole country or the world at a particular time.
60
What is surveillance?
Systematic collection and analysis of data and resultant dissemination so that appropriate measures can be taken
61
What is passive surveillance?
The most common form When labs, physicians or other HCP regularly report cases to the local health department
62
What is active surveillance?
When collection of data from the lab, physician or other HCP is initiated by the health department Often used during an outbreak investigation or research study
63
What is syndromic surveillance?
Ongoing, systematic collection, analysis, interpretation and application of real-time indicators for disease that allows for detection before public health authorities would otherwise identify them
64
What is sentinel surveillance?
a form of public health surveillance that involves monitoring a subset of the population, often a group of healthcare providers or healthcare facilities, for the early detection of infectious diseases or other health events of public health importance. E.g. for flu - in a community, a small group of healthcare providers might be selected to report the number of cases of flu they see each week. By tracking the number of cases over time, public health officials can identify spikes in activity and respond quickly with interventions such as vaccination campaigns or increased surveillance.
65
What are some uses of surveillance data?
Detecting outbreaks and clusters Identifying and monitoring health disparities Monitoring disease trends and progress Evaluating public health interventions Guiding public health policy and practice
66
What are some challenges with surveillance?
Privacy concerns Data quality and completeness Resources constraints Data sharing and interoperability
67
What are the notifiable diseases?
Acute encephalitis Acute infectious hepatitis Acute meningitis Acute poliomyelitis Anthrax Botulism Brucellosis Cholera COVID-19 Diphtheria Enteric fever (typhoid or paratyphoid fever) Food poisoning Haemolytic uraemic syndrome (HUS) Infectious bloody diarrhoea Invasive group A streptococcal disease Legionnaires’ disease Leprosy Malaria Measles Meningococcal septicaemia Monkeypox Mumps Plague Rabies Rubella Severe Acute Respiratory Syndrome (SARS) Scarlet fever Smallpox Tetanus Tuberculosis Typhus Viral haemorrhagic fever (VHF) Whooping cough Yellow fever
68
What are the notifiable organisms?
Bacillus anthracis Bacillus cereus (only if associated with food poisoning) Bordetella pertussis Borrelia spp Brucella spp Burkholderia mallei Burkholderia pseudomallei Campylobacter spp Carbapenemase-producing Gram-negative bacteria Chikungunya virus Chlamydophila psittaci Clostridium botulinum Clostridium perfringens (only if associated with food poisoning) Clostridium tetani Corynebacterium diphtheriae Corynebacterium ulcerans Coxiella burnetii Crimean-Congo haemorrhagic fever virus Cryptosporidium spp Dengue virus Ebola virus Entamoeba histolytica Francisella tularensis Giardia lamblia Guanarito virus Haemophilus influenzae (invasive) Hanta virus Hepatitis A, B, C, delta, and E viruses Influenza virus Junin virus Kyasanur Forest disease virus Lassa virus Legionella spp Leptospira interrogans Listeria monocytogenes Machupo virus Marburg virus Measles virus Monkeypox virus Mumps virus Mycobacterium tuberculosis complex Neisseria meningitidis Omsk haemorrhagic fever virus Plasmodium falciparum, vivax, ovale, malariae, knowlesi Polio virus (wild or vaccine types) Rabies virus (classical rabies and rabies-related lyssaviruses) Rickettsia spp Rift Valley fever virus Rubella virus Sabia virus Salmonella spp SARS-CoV-2 Shigella spp Streptococcus pneumoniae (invasive) Streptococcus pyogenes (invasive) Varicella zoster virus Variola virus Verocytotoxigenic Escherichia coli (including E.coli O157) Vibrio cholerae West Nile Virus Yellow fever virus Yersinia pestis
69
Outline how to report notifiable diseases?
Registered medical practitioners have a statutory duty to notify the ‘proper officer’ at their local council or local health protection team They must complete a notification form immediately on diagnosis of suspected notifiable disease and not wait for lab conformation! Send the form to the proper officer within 3 days or notify them verbally within 24 hours if urgent
70
How does CVD deaths vary in low and middle income countries?
Over 75% of CVD deaths occur in LIC and MIC but maybe this is because this is where most people live
71
What is age standardisation?
a technique used to allow statistical populations to be compared when the age profiles of the populations are quite different.
72
How do CVD rates vary in the UK?
Rates are higher in the north and Scotland compared to South
73
How does deprivation/affluence affect CHD risk?
As affluence goes up, CHD risk decreases Higher rates in the most deprived areas
74
What are the benefits of the QRISK score compared to the Framingham score?
QRISK takes into account a wider range of risk factors e.g. FHx, BMI, ethnicity and social economic status QRISK is based on recent data whereas Framingham is from data in. 1950s QRISK is better calibrated for UK population whereas Framingham is US
75
What are examples of primary prevention?
Increase exposure to protective factors e.g. vaccines Reduce exposure to risk factors e.g. modifying personal behaviour or improving services to the population e.g. clean water
76
What are examples of secondary prevention?
Screening - find people with early stages of disease and intervening E.g. smoking cessation or treating hypertension to reduce CVD risk
77
Outline the key epidemiological facts about TB in the UK?
TB incidence is concentrated in large urban areas the majority of people with TB were born outside the UK TB in England continued to disproportionately affect the most deprived populations, including groups at risk of exclusion and other health inequalities It is more likely in males, people with a history of imprisonment and people with a history of drug and alcohol misuse in the non-UK-born population with TB, homelessness, asylum seeker status and mental health needs were more common than in the UK-born population with TB