❓CARDS Flashcards
1
Q
A
2
Q
Ranolazine
A. MOA
_________________
B. Indication
_________________
C. Side Effect
A
A: 1. [pFOX inhibitor] inhibits mitochondrial enzymes of beta oxidation which relieves inhibition on pyruvate dehydrogenase.–> allowing heart to use more glucose as a fuel during MI
B: [1st line - Exertional Stable Angina] (espeically in those w/angina despite other therapy)
C. causes [Prolonged QT/INC AP duration]
- . Under normal conditions the heart can use either glucose or fatty acids to generate ATP.
- : During acute MI, fatty acids rise precipitously, and inhibit pyruvate dehydrogenase.—>glucose oxidation is depressed which is undesirable when O2 supply is limited in MI
- The net result is
- reduced lactic acid accumulation,
- less intracellular acidosis
- reduction in severity of MI
