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Flashcards in carty finkbeiner Deck (26):
1

What does all connective tissue come from?

mesenchyme

2

What are the two components of connective tissue?

extracellular matrix + cells

3

What are the two components of extracellular matrix?

protein fibers + brown substance

4

What type of cells are present in cartilage?

chondroblasts and chondrocytes, both can secrete ECM, chondrocytes are located in lacunae

5

What is in the extracellular matrix of cartilage?

-95% of cartilage is ECM
-rich in GAGs, proteoglycans

6

What is the purpose of GAGs?

negatively charged so they attract water, adding resilience and pliability

7

What is the perichondrium made of?

Dense CT, has blood vessels, nerves, fibroblast, type I fibers

8

What are the two methods of cartilage growth?

appositional growth
interstitial growth

9

What is the ECM composition of hyaline cartilage?`

-75% water
-proteoglycans
-hyaluronic acid
-type II collagen

10

Where is hyaline cartilage located?

articular surfaces, nose, larynx, tracheal rings, epiphyseal plates, fetal bone models

11

Where is there no perichondrium on hyaline cartilage?

articulating surfaces

12

What does hyaline cartilage look like histologically?

generally basophilic, can't see collagen fibers, fewer cells than elastic

13

What does the perichondrium look like histologically?

more eosinophilic, flattened cells, dense CT

14

Where are chondrogenic cells located?

perichondrium

15

Where are chondroblasts located?

near surface of cartilage (more elliptical shaped)

16

Where are chondrocytes located?

within lacunae (more rounded shape)

17

What does an isogenous group indicate?

that mitosis has just occurred, cartilage is growing

18

Which stains darker (more basophilic): territorial matrix or inter territorial matrix?

territorial matrix (around isogenous groups)

19

What is the ECM composition of elastic cartilage?

type II collagen fibers and elastic fibers (basically the same as hyaline except add elastic)

20

Where is elastic cartilage located?

pinna of ear, auditory canal, auditory tube, epiglottis

21

Does elastic cartilage have a perichondrium?

yes

22

What does elastic cartilage look like histologically?

using a special stain you can clearly see elastic fibers, more cells than hyaline but they don't like to group up

23

What is the ECM composition of fibrocartilage?

type I collagen, less proteoglycans

24

Where is fibrocartilage located?

intervertebral discs, pubic symphysis, major tendon-bone anchorages

25

Does fibrocartilage have a perichondrium?

no

26

What does fibrocartilage look like histologically?

intermediate btw dense CT and hyaline cartilage, chondrocytes are arranged in long rows, tons of type I collagen fibers, matrix is more acidophilic