Cattle 2 Flashcards
(103 cards)
What normally occurs after calving and why does metritis occur
○ Uterine fluid should be negligible 2-3 weeks after calving. - metritis - uterus does not contract properly and fluid is retained, allowing bacteria to grow.
○ Whole uterus of dairy cow should be palpable 10 days postpartum
○ Dairy cow’s uterus pre-pregnant size 40-50 days postpartum
- Lochia (uterine fluid, placental fragments, caruncles) discharged for 2 weeks postpartum
○ Normally red-brown, odourless. If it becomes stinking, uterus infected.
○ Discharge should cease by Day 30 postpartum at latest
- most bacteria are eliminated by uterine defences
Acute septic metritis (puerperal metritis) what does severity depend on, clinical signs, treatment and a major risk factor for what
- Severity of infection depends on immune system, BCS of cow, nutrition, stress, bacterial species etc …
- Clinical signs
○ Infection starts to have systemic effects
○ High temp, depressed, foul smelling redish colored uterine fluid +/- membranes
Treatment
○ Controversial - many animals don’t die!
○ RFM – if the cow is not “sick” (pyrexic) wait 5-7 days
○ Manual removal – gently – stop if blood
○ My view – pessary always; parenteral antibiotics (alamycin) if pyrexic.
§ Pessaries -> antibiotic foam
Metritis is a big risk factor for endometritis
Endometritis define, clinical signs and list some bacterial causes
- Inflammation of the endometrial lining of the uterus without systemic signs, associated with chronic postpartum infection of the uterus with pathogenic bacteria - normal 90% of cows HOWEVER if Persist beyond 3 wks – endometritis
Clinical signs
○ White discharge that DOESN’T SMELL
○ Cows are not sick
○ Causes lowered fertility if it persists
Causes
○ Arcanobacter pyogenes, Fusobacterium synergistic
○ Pseudomonas, E coli, Streptococcus,Staphylococcus,
○ clostridia - gangrenous
Endometritis how to diagnose and what is important about incidence of uterine infection after calving
○ Visually - see white pussy discharge that doesn’t smell
○ Metricheck
§ May miss some smaller cases
○ Speculum
§ Pus coming out of the vagina
○ Vaginoscopy - cervical, vaginal discharge
○ Rectal palpation - not accurate
○ Ultrasound (uterine fluid) - not common
○ Biopsy - cumbersome, deleterious result to uterus sometimes - not common
Incidence -> longer you leave uterus after calving the more likely own mechanism will get rid of infection
Endometritis list 7 risk factors
- RFMs or Metritis
- Stillbirth or calf dies within 24 hours
- Twins
- Dystocia
- Milk Fever
- Vulval discharge
- Calving induction
Endometirtis treatment and control
Treatment ○ Controversial as tends to get better with time ○ Timing is important § 2 weeks before planned start of joining -> will lead to decreased fertility Intra-uterine - metricure - cephapyrin (1st gen) Control ○ Difficult ○ Basically a nutritional problem § reduce dystocia by selective breeding § ensure clean calving environment § reduce RFM adequate feeding – esp. post partum
Pyometra pathogenesis and clinical presentation
Pathogenesis: ○ Chronic uterine infection ○ Damage to uterine wall ○ Does not produce PG ○ CL with an indefinite life span ○ No oestrus activity to remove infection presentation - Cow not sick - Uterus enlarged with doughy feel to it
Pyometra treatment and prognosis
Treatment ○ Prostaglandin to induce oestrus to get cycling then give antibiotics (intrauterine) ○ Generally an incidental finding at preg testing (empty) so don't treat as should be pregnant so just cull Prognosis ○ Unlikely to die from it ○ Often found after joining has finished ○ Treatment often not undertaken ○ More longstanding -> less fertile
Rectal examination what can palpate in what quadrants
○ Left dorsal § Rumen § Left kidney § Ovary ○ Left ventral: § Rumen § Uterus ○ Right dorsal § Left kidney § Lymph node § Small intestines § Cecum/spiral colon § Ovary ○ Right ventral § Uterus § Caecum, Intestine
Palpation of ovaries rectally what can you feel and diagnosis and list the 3 main ovarian conditions
- Pea sized, no structures (anoestrus)
- Hard lump (CL)
- Soft lump (follicle)
- Big hard lump (cyst)
- Huge (neoplasm)
Ovarian conditions
1. Post-partum anoestrus (discuss later)
2. Ovarian cyst
3. Ovarian tumour
Cystic Ovarian Disease what are they, how long persist, size, why occurs and what results in
- Anovulatory structures on ovaries
- Persist for variable periods (>10d)
- Usually larger than normal follicles (>2.5cm)
- Mainly on right ovary
- Mainly Dairy Cows, less in Beef
- Lack of LH surge leads to anovulation of dominant follicle
- Infertile if cysts persist
Increases Calving interval by 50 days
What are the 3 types of ovarian cysts and how to diagnose
1) follicular cysts
2) luteal cysts
3) cystic corpus luteum
Diagnosis
1. ultrasound
2. rectal palpation
Follicular cysts what secret, size and associated with
○ secrete either oestrogenic or androgenic steroids
○ large (>2.5 cm internal diameter, with a wall less than 3 mm thick), turgid, and thin-walled,
- can be associated with either ‘nymphomaniac’ behaviour or anoestrus
Luteal cysts structure, what secret and how similar to follicular
○ have a layer of luteal tissue in the cyst wall
○ thicker walled and less prone to rupture
○ secrete progesterone - affected cows are anoestrus
○ hard to differentiate clinically (by rectal exam) from follicular cysts, but their cause and treatment is similar so determining the difference is not particularly important.
Cystic corpus luteum how significant, when form, treat and what can cause
Incidental diagnosis made when performing ultrasound or rectal exams
○ generally no changes in the oestrous cycle observed and the cows are generally fertile
○ form after ovulation when a fluid filled cavity appears in the luteal tissue
○ do not treat them
○ They feel on rectal exam like big CLs
○ Conditions of the uterus that prevent it from producing prostaglandin can cause CLs to have a prolonged lifespan, but in these cases the CL is generally normal.
What are the 3 common outcomes for a follicular cyst and result to fertility
- Persist (for up to 70 days)
○ remain dominant over others
○ growth of other follicles suppressed by E2 and inhibin. - Regress
○ replaced by normal follicle (10-50%) - Undergoes atresia and replaced by new cyst.
○ Inter-follicular interval 8.5 to 13 days
○ Regular oestrus behaviour
What are the 4 ways to treat ovarian cyst which respond well and which dont
- Manual rupture
○ relatively low recovery rate
○ risk of ovarian haemorrhages and adhesions. - GnRH intramuscularly
○ causes the release of LH and luteinisation of the cysts (not ovulation)
○ Most cows that respond come into oestrus 18 - 23 days after treatment. - Progesterone (P4)
- Follicular cysts may best be treated using a P4 releasing device to deprive the cyst of LH. This treatment will stop nymphomania behaviour immediately. In many cases, after removal, cycling continues normally. - Ovsynch program + P4 device
Most successful unless 6 months or more then don’t respond well
Ovarian neoplasms what is the main one, diagnosis and age generally occurs
Granulosa cell tumour ○ Commonest but still rare ○ Diagnosed via palpation, ultrasound ○ All ages of cattle - not just older cattle § Even pregnant cattle
What is the difference between menstrual and oestrus cycle
- Menstrual cycle – humans, chimps
- Oestrus cycle – placental mammals
○ Do not shed the endometrium (it is resorbed)
○ Start at puberty and lasts until death, with pauses during pregnancy and after calving
○ Females only sexually active during the oestrus phase of their cycle
○ “on heat” or “in oestrus”
Bovine oestrous cycle what type, pauses, cycle length and the length of 4 phases as well as oestrus
- Polyoestrus
○ Have “cycles” from puberty until death
○ Pauses:
§ during pregnancy
§ after pregnancy (post-partum anoestrus)
○ Cycle length 18-24 days
○ 4 phases
§ Oestrus ( Day 0 - in heat)
§ Metoestrus (Days 1:5 - just had a heat)
§ Dioestrus (Days 6:17 - not much happening)
§ Pro-oestrus (Days 18:21 - about to have a heat)
○ Oestrus lasts 2 hours to 2 days
What is important about bovine oestrus in terms of farm fertility, conception rates
- Much of the activity on beef and dairy farms is directed at getting cows in calf
- Cows are only fertile during Oestrus
- Conception rates 25-60%
○ Most cows need > 1 joining
What are the 3 main structures of the ovaries
1) Corpus luteum - P4
2) Follicles - oestrogen
3) Corpus albicans
Corpus luteum and follicle where do they come from, what does it do and where does it go
Where does it come from
- CL - arises from recently ovulated follicle
Foll - follicular waves - recruitment, selection, dominant
What does it do
CL - produce progesterone (P4)
Foll - grows in response to FSH/LH and produces ostreogen
Where does it go
CL - after Prostaglandin regresses to beceome corpus albicans
Foll - LH surge make ovulate morphs into CL
Brain what are the 2 important structures for reproduction what does they respond to, release and key function in oestrous cycle
- Hypothalamus
- Responds to Oestrogen
- Releases GnRH
- Key to the Oestrus Cycle:
○ Hypothalamus Response to Oestrogen
§ Negative Feedback if P4 present
§ Positive feedback if
□ P4 has been present (“progesterone primed brain”) -> post-partum - Anterior Pituitary
- Responds to GnRH
- Produces FSH and LH
○ Also produces ACTH, TSH, GH et al