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Flashcards in Causes of Iiver disease Deck (18):

What are the possible viral infections that can cause liver disease?

Hepatitis A-E


What is Hep A

Faecal contamination of food and drink


What is Hep B

Blood/blood contamination


What is Hep C

Blood/blood contamination


What is Hep D

Have to have Hep B to get Hep D, can be acute or chronic liver disease


What is Hep E

Faecal contamination of food or drink


What is othe single most significant cause of Liver disease in the wetern world?

Chronic use of Alcohol


What does the chronic use of alcohol leaf to?

Eventually leads to Cirrhosis. Fibrous tissue scarring increases resistance to blood flow from the Portal system resulting in portal hypertension (PHT)


What is the portal system?

The system of blood vessels consisting of the Hepatic Portal Vein and its capillary network.


What does the rate of progression and regression linked to?

Further/less alcohol consumption


What are the other causes of liver disease apart from alcohol consumption and viruses?

Non-alcoholic fatty liver disease (harmless) and Non-alcoholic Steatohepatitis (can lead to cirrhosis)


What is Non-alcoholic steatohepatitis?

A pathology similar to Alcohol liver disease. Fatty build up and inflammation which can lead to Cirrhosis


What is non-alcoholic Steatohepatitis associated with?

Recognised in conditions such as obeisity, diabetes and metabolic syndrome


What are the other less common causes of liver disease?

Cholestasis, Immune disorders, Vascular abnormalities, Metabolic Disorders, Genetic Disorders


What is Cholestasis?

the blockage of bile release (intra-hepatic and extra-hepatic i.e. caused by the liver or another organ like the pancreas)


What are the different types of drug related liver disease?

Type A- dose related, withdrawl of precipitating drug results in reversal e.g. paracetamol, tetracyclines, methotrexate
Type B - Idiosyncratic (unique for each individual, can't be predicted and not dose related). Can be due to hypersensitivity or metabolic.


What seems to have increased the rate of liver disease over the years?

The increase in price of Alcohol over the years has resulted in more people dinking stronger alcohol at home


Appart from alcohol, what is another major issue involving liver disease?

Obeisity- The vast majority of the UK population who are obease have non-alcoholic related fatty liver disease