CB3

Question 1

in a 70kg man blood volume is ___

Answer 1

5.6L

Question 2

in a 70kg man blood takes up ___ % of body weight

Answer 2

7-8

Question 3

blood is ____% water and ___% solids

Answer 3

78, 22

Question 4

temp of blood

Answer 4

38 degree celcius

Question 5

ph of blood

Answer 5

7.35-7.45

Question 6

2/3 of red marrow is dedicated to ______ and 1/3 is dedicated to _______

Answer 6

leucopoiesis, erythropoiesis

Question 7

there are 500x more _____ than ____

Answer 7

erythrocytes, leukocytes

Question 8

all peripheral blood cells are derived from a single ______ stem cell

Answer 8

multipotent

Question 9

progenitor cells divide to produce (5)

Answer 9

erythrocytes, megakaryocytes, granulocytes, lymphocytes, monocytes

Question 10

differentiated cells lose their capacity for ______

Answer 10

self renewal

Question 11

stem cells acct for

Answer 11

0.1

Question 12

what do erythrocytes leave when they leave the marrow

Answer 12

they lose Cell Adhesion Molecules (CAM’s)

Question 13

what are CAM’s

Answer 13

they allow cells to leave marrow and enter circulation

Question 14

haemopoiesis requires growth factors such as (4)

Answer 14

erythropoietin, colony stimulating factors, interleukins, and thrombopoietin

Question 15

structure of hemoglobin in adults and children

Answer 15

adult = alpha2beta2
children = alpha2gamma2

Question 16

1/3 of thrombocytes are stores in blood filled spaces in _____

Answer 16

spleen

Question 17

as the fetus develops, the responibility of erythropoiesis changes from ____ to ____ to ____ to ____

Answer 17

yolk sac, liver, spleen, red bone marrow

Question 18

process in adults from stem cell to erythrocyte

Answer 18

stem cell/hemocytoblast - proerythroblast - early erythroblast - late erythroblast - normoblast - reticulocyte - erythrocyte

Question 19

1 proerythroblast turns into how many RBC’s

Answer 19

16

Question 20

RBC’s are replaced at an avg rate of ______ million cells per second

Answer 20

2-3

Question 21

haemoglobin components, such as globin, iron, and heme, can be ______

Answer 21

recycled

Question 22

what nutritional aspects affect the maturation and production of RBC’s

Answer 22

aa’s, vitamins (b12 and folate), and iron

Question 23

______ is one of the most commonly ordered laboratory tests

Answer 23

full blood count, complete blood count

Question 24

FBC/CBC measures ____ cell counts

Answer 24

RBC, WBC, and platelets

Question 25

forumla for RBC count =

Answer 25

(4-5-5.4) x 10^6 /mL or (4-5-5.4) x 10^12/mL

Question 26

reticulocytes % should equal

Answer 26

0.2 - 2

Question 27

packed cell volume measures the fraction of blood occupied by ____

Answer 27

erythrocytes

Question 28

packed cell volume should be ____ %

Answer 28

45

Question 29

hemoglobin should be __-__ g/dL in males and ___-___ g/dL in females

Answer 29

14,18,12,16

Question 30

the amt of Hb in blood is an indicator of _____ binding capacity

Answer 30

iron

Question 31

what does it mean if the mean cell volume is high

Answer 31

the size of red blood cells is high

Question 32

mean cell heamoglobin measures the _____

Answer 32

avg amt of hemoglobin in a RBC

Question 33

mean cell hemoglobin concentration is the _____

Answer 33

amt of hemoglobin per dL RBC

Question 34

range of Mean cell volume =

Answer 34

80-90 fL

Question 35

range of mean cell Hb

Answer 35

27-33 pg

Question 36

range of MCHC

Answer 36

32-35 g/dL

Question 37

clinical signs of anemia

Answer 37

fatigue and weakness, pallor, koilonychia, angular stomatitis, glossitis

Question 38

what is pallor

Answer 38

paleness

Question 39

what is koilonychia

Answer 39

nail curves upward (spoon shaped)

Question 40

what is angular stomatitis

Answer 40

deep cracks and splits at corner of mouth

Question 41

what is glossitis

Answer 41

inflammation/infection of tongue

Question 42

what is included in a basic clinical evaluation

Answer 42

review of blood count/blood smear, RBC indices, reticulocyte index, and determination of short term/long term

Question 43

what are the 2 types of hypochromic-microcytic anaemia

Answer 43

iron deficiency and STOPPED AT SLIDE 32 CB3