CBC Flashcards

(66 cards)

1
Q

What does a CBC include?

A
  • WBC
  • RBC
  • Hemoglobin, hematocrit, red cell indices
  • platelets
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2
Q

What’s a normal total WBC?

A

4500-11000

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3
Q

What’s a normal total WBC for <2 years ?

A

6200-17000

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4
Q

What’s a normal total WBC for infants?

A

9000-30000

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5
Q

T/F: elderly may not have a high white count in setting of infection

A

t

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6
Q

What are critical WBC values?

A

<2000, >40,000

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7
Q

What do these cause
- bone marrow failure
- viral infection
- aplastic anemia
-vitamin deficiencies
- B12 or iron deficiencies
-autoimmune diseases
-drug toxicity

A

decreased WBC (leukopenia)

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8
Q

What do these cause
-inflammation
-infection
-leukemia
-malignancies
-vascular conditions
-tissue necrosis
-steroids*
-stress from trauma
-seizures/uncontrolled shivering
-thyroid storm
-dehydration

A

elevated WBC (leukocytosis)

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9
Q

____ can mimic leukemia

A

sepsis

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10
Q

Differential count = % of each type of leukocyte present

A

including granulocytes + nongranulocytes

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11
Q

First responders to bacterial infections, elevated in bacterial infections, trauma, or stress

A

neutrophils

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12
Q

Elevated in allergies, asthma, or parasitic infections

A

eosinophils

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13
Q

involved in inflammatory responses, rarely elevated but seen in CML - allergens, parasites, pathogens

A

basophils

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14
Q

elevated in viral infections, chronic inflammation, certain cancers

A

lymphocytes

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15
Q

engulf pathogens, increased in chronic infections, TB, and certain leukemias

A

monocytes

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16
Q

Neutrophils are produced in ____ days, only live for ____ hours

A

7-14 days, 6 hours

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17
Q

When are neutrophils elevated? (neutrophilia)

A

inflammation (RA, thyroiditis), cushing syndrome

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18
Q

When are neutrophils decreased (neutropenia)?

A

drugs, chemo/radiation, anaplastic anemia, viral infections (measles, hepatitis, influenza)

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19
Q

Leukocytosis + neutropenia =

A

SEPTIC BILLS
Severe bacterial infection
Exercise
Postsplenectomy
Trauma
Inflammation
Corticosteroids
Burns
Infarction
Leukemia
Loss of blood
Surgery/smoking

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20
Q

mature, segmented nucleus

A

segmented neutrophils

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21
Q

less mature neutrophils, have an unsegmented nucleus shaped like a C

A

band neutrophils

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22
Q

left shift

A

increase in immature cells, often from bacterial, inflammation, tissue damage

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23
Q

indicates a patient’s real risk of infection

ANC = WBC x (%neutrophils + bands)

A

absolute neutrophil count (ANC)

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24
Q

What’s a normal ANC ?

A

2500-8000

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25
What does <1000 ANC indicate?
immunosuppression-- isolate patient!
26
T/F: eosinophils + basophils change due to bacterial or viral infection
false
27
Seen in chronic bacterial and acute viral infections
lymphocytes
28
largest WBC that lasts longer in circulation, search + destroy pathogens and infected cells, producing cytokines to help control infections, and help engulf dead or damaged cells + help regeneration of injured tissue
monocytes
29
What's a normal RBC?
3.9-5.5x10^6
30
What does RBC count measure
direct count, assess overall RBC production + size
31
Decreased RBCs
all types of anemia
32
increased RBCs
elevated WBCs, polycthemia vera, OSA
33
Normal Hct (m)
40-54%
34
Normal Hct (f)
36-48%
35
Normal hemoglobin (m)
13.8-17.2
36
Normal hemoglobin (f)
12.1-15.1
37
elevated hemoglobin
dehydration, burns, vomiting
38
decreased hemoglobin
anemia
39
average size of RBCs
MCV
40
average amount of Hbg per RBC
mean corpuscular hemoglobin (MCH)
41
concentration of hemoglobin in given volume of RBCs
mean corpuscular hemoglobin concentration (MCHC)
42
variation in size of RBCs
red cell distribution width (RDW)
43
normal platelet count
150k-450k
44
Elevated platelets
thrombocytosis = myeloproliferative disorders
45
decreased platelets
thrombocytopenia = bleeding risk, DIC
46
T/F: some conditions can artifically affect results
T
47
What can increase results?
adrenaline, allopurinol, aspirin, heparin, steroids
48
What can decrease results?
antibiotics, anticonvulsants, antihistamines, antithyroid, chemo
49
When to order a CBC?
1) diagnose, monitor, assess 2) patient with fatigue, pallor, SOB 3) chills or sepsis 4) unexplained bruising, prolonged bleeding 5) general screening
50
leukocytosis vs leukopenia
infection/inflammation vs bone marrow dysfunction
51
thrombocytosis vs thrombocytopenia
bleeding risk vs myeloproliferative disorder
52
universal recipients
AB
53
universal donors
O
54
protein on RBC that determines + or -
Rh factor
55
protein on surface of cells that help body determine self
HLA - human leukocyte antigen
56
packed RBCs
retain characteristics of whole blood except 250ml of platelet-rich plasma
57
washed blood products
RBC or platelet products
58
irradiated blood products
exposed to radiation
59
FFP
uncoagulated plasma separated from RBCs, used for blood loss, coagulation, warfarin reversal
60
frozen blood product created from donor's plasma, for hemophilia A, fibrinogen deficiency
cryoprecipitate
61
fractionation of pooled plasma
albumin
62
83% albumin, 17% globulin
plasma protein fraction
63
hemopure
synthetic blood subsitute
64
indications for transfusion
- significant blood loss - symptomatic anemia -dropping Hgb or Hct levels -decreased clotting factors
65
allergic reaction to transfusion
antihistamines
66
febrile transfusion reaction
antipyretics + antihistamines