Flashcards in CC: B Vitamins Deck (24)
What is Vitamin B1?
What enzymes absolutely require Thiamine/B1?
PDH (pyruvate to A-CoA)
alpha-Ketoglutarate Dehydrogenase (Step 4 TCA Cycle a-KG to Succinyl-CoA)
Transketolase (used TWICE in HMPS/Pentose Pathway/Phosphoglucanate)
What results from Thiamine/B1 deficiency?
BeriBeri Dry (CNS encephalopathy + psychosis)
BeriBeri Wet (Cardiovascular)
Cats, Ruminants, Horses DRY BeriBeri
Pigs WET BeriBeri
Why do Cats have a particular predisposition towards Thiamine/B1 deficiency?
Raw/undercooked fish contain high enough levels of THIAMINASE to affect the kitties
What was discussed as a reason for Ruminants to have a thiamine deficiency?
Certain plants found country-wide contain THIAMINASE.
Bracken Fern and Horsetails in particular.
What do you see in Horses with Thiamine/B1 deficiency?
CNS signs. Anorexia, weight loss, incoordination, *hind limb abduction* (due to lack of ATP for nerves).
Can die within 2-10 days.
What is Vitamin B2?
What is Riboflavin/B2 utilized in the body for?
FAD (flavin adenine dinucleotide)
Does Riboflavin/B2 have any identifying characteristics?
YES. Its ORANGE-YELLOW color.
How would an animal with a Riboflavin/B2 deficiency present as?
Poor growth, failure to thrive, weakness, ataxia, dermatitis, alopecia
Skin problems, and issues with energy.
What is Vitamin B3?
What is Niacin/B3 utilized in the body for?
NAD(H) and NADP(H)
What happens to the body in a Niacin/B3 deficiency?
Dermatitis (skin), Diarrhea (GI), Dementia (CNS), Death
Canine BLACK TONGUE --related to Skin issues
What is Vitamin B4?
DOESN'T EXIST SUCKA!!
What is Vitamin B5?
What is Pantothenic Acid/B5 utilized in the body for?
Acetyl Coenzyme A
What is Vitamin B6?
What is Pyroxidine/B6 utilized in the body for?
Neurotransmitters, AA transferases (gluconeogenesis), and glycogen phosphorylase
What is Vitamin B7?
What is Biotin/B7 utilized in the body as?
Pyruvate Carboxylase -- the first enzyme in the gluconeogenic pathway
These are essential for Gluconeogenesis
Where does Biotin/B7 come from?
pretty much everywhere
What happens in times of Biotin/B7 deficiency?
Deficiencies are Rare due to it's widespread nature, but:
Decreased appetite & growth, Dermatitis, Alopecia, weak nails, achromatrichia (different colored hoof), Hepatic stenosis, Ketoacidosis, Hyperammonemia, Coma, Death
Since Biotin/B7 is so widespread, how could we see a deficiency?
Egg Whites contain AVIDIN. Avidin binds Biotin avidly.
So beware a diet with high levels of RAW Egg Whites.