Cell Bio Lecture 5 - Cytoskeleton I Flashcards
(14 cards)
Which fiber is responsible for organelle transport?
Microtubules.
What core protein makes up microtubules?
Tubulin
What direction is retrograde transport?
Towards the nucleus
What direction is orthograde transport?
Away from the nucleus
Does MT movement require ATP?
Yes, dynein and kinesin hydrolyze ATP
What fiber are centrosomes comprised of?
Microtubues.
What are two examples of axonemes? What fiber are they comprised of?
Cilia and flagella, they are mitrotubule-based structures.
What do basal bodies do?
They anchor axonemes (cilia in most cases)
What is the molecular defect in patients with Kargegener’s/Primary Ciliary Dyskinesia/Immotile Cilia Syndrome?
They lack dynein on their microtubules.
What does the drug Taxol do and what is it used to treat?
It is an anti-tumor drug. It freezes the mitotic spindle in the aster stage, preventing disassembly of the mitotic spindle.
Colchicine, colcemid, vinblastine, and vincristine are examples of vinca alkaloids. What do they do?
They also treat cancer (and colcemid treats gout, too). They prevent mitotic spindle formation.
What is the mechanical defect in dementia Tau-opathy?
The Tau protein is a MT-associated protein and it sits on the (+) end of the MT. In these patients, the protein is either missing or defective so the MTs cannot regulate length properly.
What is the motor unit for retrograde transport?
Dynein
What is the motor unit for orthograde transport?
Kinesin
