Cell Bio Lecture 5 - Cytoskeleton I Flashcards

(14 cards)

1
Q

Which fiber is responsible for organelle transport?

A

Microtubules.

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2
Q

What core protein makes up microtubules?

A

Tubulin

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3
Q

What direction is retrograde transport?

A

Towards the nucleus

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4
Q

What direction is orthograde transport?

A

Away from the nucleus

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5
Q

Does MT movement require ATP?

A

Yes, dynein and kinesin hydrolyze ATP

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6
Q

What fiber are centrosomes comprised of?

A

Microtubues.

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7
Q

What are two examples of axonemes? What fiber are they comprised of?

A

Cilia and flagella, they are mitrotubule-based structures.

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8
Q

What do basal bodies do?

A

They anchor axonemes (cilia in most cases)

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9
Q

What is the molecular defect in patients with Kargegener’s/Primary Ciliary Dyskinesia/Immotile Cilia Syndrome?

A

They lack dynein on their microtubules.

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10
Q

What does the drug Taxol do and what is it used to treat?

A

It is an anti-tumor drug. It freezes the mitotic spindle in the aster stage, preventing disassembly of the mitotic spindle.

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11
Q

Colchicine, colcemid, vinblastine, and vincristine are examples of vinca alkaloids. What do they do?

A

They also treat cancer (and colcemid treats gout, too). They prevent mitotic spindle formation.

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12
Q

What is the mechanical defect in dementia Tau-opathy?

A

The Tau protein is a MT-associated protein and it sits on the (+) end of the MT. In these patients, the protein is either missing or defective so the MTs cannot regulate length properly.

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13
Q

What is the motor unit for retrograde transport?

A

Dynein

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14
Q

What is the motor unit for orthograde transport?

A

Kinesin

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