Cell Bio Lecture 6 - Cytoskeleton II Flashcards
(25 cards)
List the three cytoskeleton components in order of size from smallest to largest.
Microfilaments, intermediate filaments, microtubules.
What two diseases “hijack” actin filament growth machinery?
Vaccinia (the poxes like smallpox), and listeria.
Lamins are found in what cell types? What class of cytoskeleton component is it?
All nucleated cells. It is a type of intermediate filament.
Vimentin is found in what cell types? What class of cytoskeleton component is it?
Most mesenchymal cells, including endothelial cells and fibroblasts. It is a type of intermediate filament.
Desmin is found in what cell types? What class of cytoskeleton component is it?
Muscle cells. It is a type of intermediate filament.
Glial fibrillary acidic protein (GFAP) is found in what cell types? What class of cytoskeleton component is it?
Glial cells (astrocytes). It is a type of intermediate filament.
Neurofilamin is found in what type of cell? What class of cytoskeleton component is it?
Neurons. It is a type of intermediate filament.
Keratin is found in what type of cell? What class of cytoskeleton component is it?
Epithelial cells. It is a type of intermediate filament.
What does taxol do?
It freezes spindles in the aster stage, preventing disassembly (spindles are microtubues)
What does colchicine do?
It prevents spindle assembly (MT structure)
What does vinblastine do?
It prevents spindle assembly (MT structure)
What do hemidesmosomes connect?
It anchors the epithelium to the basal lamina
What do desmosomes do? What protein anchors them?
They are a cell-cell junction between epithelial cells. Keratin is the protein.
What is the microfilament analogue of a basal body of the microtubule-based axonemes?
The terminal web anchors microvilli.
What are the MT accessory proteins?
MAPs, Tau
Name the class of cytoskeletal component that makes up a sacromere.
Microfilament.
Name the class of cytoskeletal component that makes up microvilli.
Microfilament.
Phagocytosis is a _________ based function.
Actin (microfilament)
Cell motility is a _________ based function.
Actin (microfilament)
Cytokinesis is a is a _________ based function.
Actin (microfilament)
Force generation is a is a _________ based function.
Actin (microfilament)
What structure plays a major role in erythrocyte membrane stability?
Actin (microfilament)
Blistering disease is likely due to a defect in what?
Intermediate filaments or the proteins that make them. Desmosomes and hemidesmosomes are unable to form.
To what cytoskeletal structure can hereditary spherocytosis be attributed?
Microfilaments (actin) - mishpapen RBCs.
