Cell Cycle Non Specific Drugs Flashcards
(21 cards)
Treatment of hodgkins lymphoma and melanoma
Dacarbazine
Undergoes bio transformation into MTIC which forms methyl carbonium ions that attack nucleophilic groups on dna
Dacarbazine
Chronic lymphoma leukaemia treatment by
Chlorambucil
Chronic myelogenous leukemia
Busulfan
Treatment of brain tumours as they are lipid soluble and penetrate the blood brain barrier
Lomustine and carmustine
Sugar containing nitrosurea that treats insulinoma as it is cytotoxic to beta cells of pancreas
Streptozocin
Induces type 1 diabetes in animals for research
Has high oral bioavailability
Cyclophosphamide
Treatment for breast and ovarian cancers, also metabolises acrolein, causes hemorrhagic cystitis dur to acrolein in urine
Cyclophosphamide
Irritation and fibrosis of bladder
Cyclophosphamide
How can irritation and fibrosis of bladder be treated
By proper hydration and IV of MESNA
Causes syndrome of inappropriate ADH secretion
Cyclophosphamide
Can cause lymphocytopenia
Mechloroethamine
An example of alkyl sulfonate
Busulfan
A reactive agent that forms hydrogen peroxide which generate free radical which caused DNA strand scission
Procarbazine
Leukemogenic drug
Used in clinical regiments for Hodgkins and non-Hodgkins lymphoma
Procarbazine
Used in treatment of multiple myeloma
Melphalan
The dose of melphalan is carefully adjusted by monitoring ___
Platelet and WBC count
What are the three platinum analogues?
Cisplatin
Carboplatin
Oxaliplatin
What is a 3rd generation drug that is a platinum analog
Oxaliplatin
Myelotoxic drug that is a platinum analog
Carboplatin
Used for solid tumours and is a platinum analog
Cisplatin
