Cell signalling Flashcards
(8 cards)
1
Q
Pathway for TLR4 to NFKB
A
TLR4 TIR MyD88 IRAK 4 IRAK 1 TRAF 6 TAK 1 IKK
2
Q
NFKB Subunits
A
REL A REL B C REL NFKB 1 NFKB 2
3
Q
NFKB Structure
A
Dimer, either homodimer or heterodimer
4
Q
Microbial ligand for TLR4
A
LPS
5
Q
Canoconial pathway for NFKB
A
IKKb and y becomes activated and phosphorylates IkB. IkB is then degraded by proteasomes. This leaves the NFKB dimers REL and p50 free to translocate to the nucleus and activate the genome
6
Q
What is canonical pathway activated by
A
TNFa, IL 1, TLR
7
Q
What is alternative activated by
A
LT, CD40L, RANKL
8
Q
How doe sallternative pathway work
A
IKKa and NIK breakdown p100 ( precursor for p52). This leaves p52 and REL B to act on the genlme
