Cells & Tissues of the Immune System

Question 0

Types of T cells

Answer 0

Tgamma-delta, Talpha-beta

Question 1

Lymphocytes

Answer 1

B lymphocytes

T lymphocytes

Question 2

Types of Talpha-beta cells

Answer 2

CD4 => Th1, TH2, TH17, Tfh, Treg

CD8

Question 3

T cell surface markers

Answer 3

CD4, CD8, CD3

Question 4

B cell surface markers

Answer 4

CD79

Question 5

B cell function

Answer 5

secrete Abs

Question 6

B cell Ag Receptor

Answer 6

membrane form of Ig (IgM or BCR)

Question 7

B cell location in secondary lymphoid tissues

Answer 7

follicles (nodules)

Question 8

general helper T cell functions

Answer 8

help adaptive immune responses by activating other cells

Question 9

Th1 function

Answer 9

activate macrophages

Question 10

Th2 function

Answer 10

activate eosinophils

Question 11

Th17 function

Answer 11

activate neutrophils

Question 12

Tfh function

Answer 12

activate B cells

Question 13

Treg function

Answer 13

inhibit adaptive immune responses & help avoid immune responses to “self” Ags

Question 14

Tc function

Answer 14

kill cells that express Ags of intracellular pathogens

Question 15

T cell Ag receptor

Answer 15

TCR

Question 16

Location of T cells in secondary lymphoid tissues

Answer 16

diffuse tissue

Question 17

Types of Primary Lymphoid Tissues

Answer 17

bone marrow, thymus, cloacal bursa, ileal Peyer’s patches

Question 18

Primary Lymphoid Tissue def.

Answer 18

where lymphocytes mature from precursor cells

Question 19

Where do all lymphocytes originate from precursors in?

Answer 19

bone marrow

Question 20

T cells mature in

Answer 20

the thymus

Question 21

B cells mature in the

Answer 21

cloacal bursa, ileal Peyer’s patches, bone marrow

Question 22

Secondary Lymphoid Tissue def

Answer 22

where mature lymphocytes encounter Ag & are activated in adaptive immune responses.

Question 23

Types of Secondary Lymphoid Tissues

Answer 23

spleen, lymph nodes, Mucosa-Associated Lymphoid Tissues (tonsils, intestinal Peyer’s patches, lymph nodes draining mucosal tissues)

Question 24

Function of secondary lymphoid tissues

Answer 24

filter foreign antigens

Question 25

spleen filters

Answer 25

blood-borne antigens

Question 26

Mucosa-Associated Lymphoid Tissues (MALT) filter

Answer 26

Ags entering at mucosal surfaces

Question 27

Lymph Nodes filter

Answer 27

Ags in any tissue that it drains

Question 28

Mucosal Immune System lymphoid tissues are

Answer 28

different than other lymphoid tissues

Question 29

Anatomic features of mucosal immune system

Answer 29

- intimately associated with epithelium | - specialized Ag uptake mechanisms (M cells)

Question 30

Effector mechanisms of mucosal immune system

Answer 30

- Activated/memory T cells predominate - Activated Treg cells present - Secretory IgA - Distinctive microbiota

Question 31

Immune regulation of mucosal immune system

Answer 31

- active suppression predominates (food) | - inhibitory macrophages & DCs

Question 32

Naive lymphocytes

Answer 32

lymphocytes that haven't previously recognized Ags & been activated

Question 33

naive lymphocytes circulation patterns

Answer 33

circulate between blood and secondary lymphoid tissues

Question 34

How do lymphocytes enter the spleen from the bloodstream?

Answer 34

directly via the blood

Question 35

How do lymphocytes enter lymph nodes & Peyer's patches from the blood stream?

Answer 35

via venules with specialized endothelial cells in diffuse tissue

Question 36

How do Ags & DC carrying Ags move from infected tissue to lymph nodes?

Answer 36

via lymphatic vessels

Question 37

Mucosal lymphatic tissues get Ags and DC from..

Answer 37

mucosal surface and lamina propria

Question 38

memory lymphocytes circulation pattern

Answer 38

tend to return to type of lymphoid tissue where they were first activated with minimal cross-over

Question 39

mucosal infection vaccines (resiratory, GI)

Answer 39

provide better local immunity if given at mucosal site but have shorter duration of immunity compared to systemically administered vaccines

Question 40

Effector B cell circulation patterns

Answer 40

migrate from follicular tissues into medullary cords (lymph nodes), red pulp (spleen), lamina propria (mucosal-associated lymphoid tissue) or bone marrow.

Question 41

where is most plasma cell IgG production done?

Answer 41

bone marrow

Question 42

Effector T cell circulation patterns

Answer 42

migrate from lymphoid tissues into infected tissues, where they're needed to do their effector functions