CellSig7 - 15 Flashcards Preview

Y2S2 - Cell Signalling > CellSig7 - 15 > Flashcards

Flashcards in CellSig7 - 15 Deck (15):
1

What do many GPCR activate?

PI - increasing the activity of phospholipase C-b

2

What do many RTK activate?

Phospholipase C-g and PI3-kinase

3

What does phospholipase C-b catalyse the production of?

Inositol trisphosphate

4

What does phospholipase C-g catalyse the production of?

Diacylglycerol

5

What does PI stand for?

Phosphotidyl inositol

6

Outline a PI pathway

GPCR activation > Gq activation > phospholipase C-b activation > separation of PIP2 and IP3 > IP3 gated Ca release > activation of PKC/PIP2 complex

7

What can phospholipase A2 do?

Generate arachadonic acid (AA) from hydrolysis of PIP2

8

What is AA?

Arachadonic acid - precursor for hormone i.e. prostaglandins, leukotrienes and thromboxanes

9

What is PIP2?

PI(4,5)P2

10

What does diaglycerol do?

Activates PKC

11

What is DAG?

Diaglycerol

12

What can diacylglycerol kinase (DGK) do?

Phosphorylate DAG to form phosphatidic acid (precursor of PI)

13

What links PI-3-kinase to tyrosine phosphorylate transmembrane receptors?

P85 in the SH2 and SH3 domain

14

What does PTEN stand for?

Phosphatase and tensin homologue

15

What is PTEN?

Tumour supressor