Flashcards in CellSig7 - 15 Deck (15):
What do many GPCR activate?
PI - increasing the activity of phospholipase C-b
What do many RTK activate?
Phospholipase C-g and PI3-kinase
What does phospholipase C-b catalyse the production of?
What does phospholipase C-g catalyse the production of?
What does PI stand for?
Outline a PI pathway
GPCR activation > Gq activation > phospholipase C-b activation > separation of PIP2 and IP3 > IP3 gated Ca release > activation of PKC/PIP2 complex
What can phospholipase A2 do?
Generate arachadonic acid (AA) from hydrolysis of PIP2
What is AA?
Arachadonic acid - precursor for hormone i.e. prostaglandins, leukotrienes and thromboxanes
What is PIP2?
What does diaglycerol do?
What is DAG?
What can diacylglycerol kinase (DGK) do?
Phosphorylate DAG to form phosphatidic acid (precursor of PI)
What links PI-3-kinase to tyrosine phosphorylate transmembrane receptors?
P85 in the SH2 and SH3 domain
What does PTEN stand for?
Phosphatase and tensin homologue