Central Nervous System Flashcards

(34 cards)

1
Q

Where is white willow found?

A

Europe, moist habitats (riverbanks)

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2
Q

What has white willow bark been used for in the past?

A

chronic pain, fevers, headache, gout

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3
Q

Who provided a detailed account of the use of white willow bark for treating gastrointestinal pain and chronic inflammation?

A

Leonard Fuchs

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4
Q

What phenolics does white willow contain and what are their properties?

A

salicin and salicylic acid which have pyretic (fever reducing) and analgesic (pain relieving) properties, and salicylic acid is an anti-inflammatory agent

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5
Q

What are side effects of white willow phenolics?

A

gastric discomfort and nausea

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6
Q

What company investigated salicylic acid?

A

Bayer

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7
Q

What was the product called that Bayer semi-synthesized?

A

acetylsalicylic acid (ASA), patented as Aspirin

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8
Q

What are effects of ASA?

A

antipyretic, analgesic, and anti-inflammatory; also can reduce the risk of heart attack and stroke, and is an effective treatment for angina

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9
Q

Identifying traits of capsicum pepper

A

perennial herb, Solanaceae (tomato) family, native to South and Central America

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10
Q

What are the two varieties of pepper?

A

tabasco type, and habanero type

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11
Q

What causes the hotness of the capsicum pepper?

A

the proto-alkaloid capsaicin (concentrated where the seeds are)

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12
Q

Where is capsaicin absent?

A

seeds, leaves, stems, and roots

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13
Q

The burning sensation is caused by capsaicin binding to what receptors?

A

Vanilloid ion-channel receptors

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14
Q

What does the capsaicin binding result in?

A

A false signal sent to the brain that mimics the sensation of heat

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15
Q

Why are capsicum peppers popular?

A

The perception of pain stimulates the release of endorphins which results in a pleasurable sensation

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16
Q

What are the medicinal properties of capsaicin?

A

can be used as a topical analgesic to relieve pain for minor muscle aches, arthritis pain, and sprains; relief from skin rashes and psoriasis; and shingles
also has anti-fungal, anti-microbial and anti-cancer properties; kills prostate cancer cells and inhibits leukemia cell growth

17
Q

Identifying traits of valerian

A

herbaceous perennial native to Europe

18
Q

How did Ancient Greeks use valerian?

A

to treat digestive and urinary tract disorders

19
Q

What is the sedative effect of valerian root attributed to?

A

valepotriates (valerenic acid and valtrate) and a number of essential oils (terpenoids)

20
Q

What has valerian been used for historically?

A

first nervous afflictions (hysteric complaints) and an effective sedative for decreasing stress, anxiety, and sleep disorders; nervous tension; promotes sleep

21
Q

Identifying traits of St. John’s wort

A

European, perennial herb

22
Q

How was St. John’s wort used in Middle Ages?

A

Was said to have magical powers, and apparently repelled evil spirits. Folk healers have used it to treat depression, anxiety, and insomnia.

23
Q

What are the secondary products of St. John’s wort and how do they work?

A

hypericin and hyperforin; inhibit reuptake of 5 major neurotransmitters and hyperforin has antibiotic and anti-viral properties

24
Q

What drug does St. John’s wort outsell in Germany?

A

Fluoxetine (Prozac)

25
Identifying traits of ginkgo
likely indigenous to China but is a cultigen, tree, distinct sexes
26
How far back have ginkgo fossils been dated?
Jurassic period
27
What was ginkgo used for in traditional Chinese medicine?
seeds were used to treat asthma, coughs, and bladder problems; leaves were used to improve blood circulation, treating skin disorders, and as a plaster to heal wounds
28
What do ginkgo extracts do?
promotes vasodilation (opening of blood vessels) which improves blood flow and therefore treats short-term memory loss, arterial diseases (vericose veins), depression, cognitive problems and inner ear disorders
29
What are ginkgo benefits to elderly patients?
improve memory, concentration, and overall alertness, reduced pain when walking, and relief from vertigo
30
What are the active principles of ginkgo?
a group of related diterpenoids called the ginkgolides A-C; they are free radical scavengers that promote nerve cell viability, increase blood flow (preventing progress of dementia, which is caused by insufficient oxygen levels in the blood)
31
Identifying traits of caucasian snowdrop
perennial, herbaceous, Daffodil family, native to Europe and west Asia
32
How has the snowdrop been used medicinally?
treat muscle tissue disease, abnormal muscle weakness, and polio
33
What's the alkaloid in snowdrops and what does it do?
galantamine, inhibits acetylcholinesterase
34
What is galantamine used for?
Treats Alzheimer's disease, increases acetylcholine levels in the brain; enhances the memory of brain damage patients