Cephalosporins Flashcards
What are the 3 1st gen cephs? which is the only IV one? what roa is cephalexin?
Cephalexin (PO), Cefazolin (IV), Cefadroxil (PO)
What are the three 2nd gen cephs? what is their ROA? sp roa for cerfuroxime?
“furox is a pro fox”
Cefuroxime (PO and IV), cefprozil (PO), Cefoxitin (IV)
what are the four 3rd gen cephs?
- which is the only PO one?
“TAZ TRIES to FIX his TAXES”
Ceftazidime, ceftriaxone, cefixime, cefoaxime
- ALL IV except CEFIXIME (PO).
What is the one 4th gen ceph? roa?
Cefipime (IV only)
What are the two 5th gen cephs? which is the only one available in canada?
ceftobiprole and ceftaroline (not availabile in canada).
- both IV
Describe the spectrum activity of the diff generations of cephalosporin against MSSA
- 1st and 4th Gen : have best MSSA coerage.
- 2nd and 3rd gens: worse than 1st and 4th
- 5th gen: best staph coverage, incl. MRSA
Which Gen is the only ceph to cover MRSA?
5th gens.
What are the only 2 cephalosporins that cover pseudomonas?
cefipime and ceftazidime
Which cephalosporins cover Bacteroidis fragilis?
Cefoxitin
Describe activity against strep?
Gets better as gens go up.
How effective are cephalosporins (as a group) against Enterococci and Atypicals (Mycoplasma and Chlamydia Pneumoniae)?
None
Describe teh Gram negative coverage as go from 1st to 2nd gens… what GRAM negs do the following gens cover?
1?
2?
3?
4?
5?
1st) PEK
2nd) MB HPEK
3rd) MB HENPEK + pseudomonas (TAZ only)
4th) Enhanced activity against 3rd gen organisms incl more actiivty against SPICE A organisms.
5th) Similar to 3rd gens.
LEGEND:
● Haemophilus influenzae
● Enterobacter* (AmpC induction)
● Neisseria
● Proteus
● E. coli
● Klebsiella
● M. catarrhalis
● B. burgdorferi
Do cephalosporins cover oral anaerobes?
yes!
Do any cephalosporins cover C. diff?
no!
