Cervical Cancer

Question 1

What percentage of cervical cancers are caused by HPV infection?

Answer 1

More than 90%

HPV 16 and 18 are high-risk strains responsible for 70% of cases.

Question 2

What surgical procedure is preferred for localized cervical cancer?

Answer 2

Open radical hysterectomy

It is preferred over laparoscopic or simple hysterectomy.

Question 3

What does the LACC trial indicate about minimally invasive surgery for cervical cancer?

Answer 3

Lower DFS and lower OS

This was confirmed in subsequent retrospective reviews and meta-analyses.

Question 4

In which stage of cervical cancer can women be cured with less extensive surgery?

Answer 4

Stage IA1

This is an exception to the preference for open radical hysterectomy.

Question 5

What is the standard-of-care treatment for high-risk, locally advanced cervical cancer?

Answer 5

Concurrent chemoradiation with pembrolizumab

This includes weekly cisplatin and radiotherapy, followed by pembrolizumab maintenance.

Question 6

What clinical trials support the use of pembrolizumab in cervical cancer treatment?

Answer 6

ENGOT-cx11/GOG-3047/KEYNOTE-A18

These trials focus on PD-L1 positive patients.

Question 7

What is the preferred first-line treatment for metastatic cervical cancer that is PD-L1 positive?

Answer 7

Cisplatin, paclitaxel, bevacizumab, and pembrolizumab

The addition of pembrolizumab prolongs OS and PFS.

Question 8

What can be substituted for cisplatin in the treatment of metastatic cervical cancer?

Answer 8

Carboplatin

This substitution is applicable in the preferred treatment regimen.

Question 9

What is Tisotumab-vedotin?

Answer 9

An antibody-drug conjugate targeting tissue factor

It is approved for second-line treatment of metastatic cervical cancer.