Ovarian Cancer Flashcards
(10 cards)
What should all patients with a diagnosis of ovarian, fallopian, or peritoneal carcinoma undergo?
Genetic risk evaluation
This is crucial for understanding hereditary cancer risks and guiding treatment options.
What is considered optimal cytoreduction?
<10 mm of residual disease at the end of surgery
The degree of residual disease is strongly associated with overall survival (OS).
What is the first line management for early stage IA or IB ovarian cancer?
Consider surgery alone
This applies only when the disease is localized to the ovary.
What is the first line management for other types of epithelial ovarian cancer (EOC)?
Surgery (if candidate) and adjuvant platinum-based chemotherapy (platinum/taxane 6 cycles)
Maintenance treatment may include PARP inhibitors if BRCA positive or HRD.
What treatment options are considered for patients with platinum-resistant EOC?
Mirvetuxemab if FOLR1 expression, single agent chemotherapy (consider adding Bev)
This reflects the need for personalized treatment approaches based on tumor characteristics.
What is the second line management for platinum sensitive EOC?
Carbo/taxol
This regimen is typically used after initial platinum-based chemotherapy.
How are Ovarian Germ Cell Tumors generally treated?
Like testicular germ cell tumors with BEP
BEP stands for Bleomycin, Etoposide, and Cisplatin.
What is a potential maintenance treatment for patients with BRCA+ or HRD after initial EOC treatment?
PARP maintenance
This is aimed at exploiting the DNA repair deficiencies in these tumors.
True or False: All patients with ovarian cancer should receive the same treatment regardless of genetic factors.
False
Genetic evaluation plays a crucial role in determining personalized treatment plans.
Fill in the blank: The degree of residual disease remaining after debulking is very strongly associated with _______.
overall survival (OS)
This highlights the importance of achieving optimal cytoreduction.
