Ch 1 Immune Mechanisms Flashcards Preview

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Flashcards in Ch 1 Immune Mechanisms Deck (29):
1

genes that encode MHC are located on what chromosome? B2 microglobulin?

6 (short arm); 15

2

what order are the regions of MHC molecules encoded on chrom 6?

class II (HLA -DP, DQ, DR) class III, and class I (HLA- a,b,c)

3

what does class III MHC polypeptide region encode?

complement (Factor B, C4, C2); TNFa, lymphotoxin a & b; HSP

4

besides MHC II peptides, what other proteins are encoded on chrom 6 class II region

HLA-E (NK cell recognition), HLA-F (localized to ER and Golgi), HLA-G (on fetal derived placental cells), HLA-H (iron metabolism)

5

How do HSV and CMV evade MHC I presentation?

block TAP; remove class I molecule from ER, respectively

6

in MHC II processing, what occupies the binding cleft and what protein facilitates?

in ER, invariant chain is in binding cleft, cleaved to CLIP in vesicle by proteolytic enzymes, then HLA-DM (intracellular protein) removes CLIP for peptide to be bound

7

IPEX

immune dysregulation due to mutation in foxp3; characterized by watery diarrhea, eczema and endocrinopathy

8

what is Bim?

pro-apoptotic factor in the BCL2 family. activated by t cells binding self-antigen without costimulation. apoptosis occurs through mitochondrial pathway

9

what does FasL do?

FasL (cd95L) binds with Fas (cd95) on same or nearby cells when t cell is self reactive. leads to apoptosis via caspase cascade

10

what is Alps caused by and what is it?

mutation in Fas or caspase 10; lymphocytes don't know when to die and they accumulate in lymph tissue and there are autoimmune problems

11

What is the receptor for CCL5 (RANTES)

CCR1, 3, 5

12

CCL11 (eotaxin)

CCR3

13

CCL17 (TARC)

CCR4

14

CXCL8 (IL8)

CXCR1, 2

15

CCL17, CCL22

CCR4 (pro Th2 response)

16

mutation in what confers malaria protection?

DARC/duffy (mutation in GATA of DARC gene)

17

ICAM1

CD54 binds LFA1 and MAC1, binding for Rhinovirus A and B

18

ICAM2

CD102 binds LFA1

19

icam3

cd50 binds LFA1 and CD18

20

icam4

CD 242 binds LFA1 and CD18

21

vcam1

cd106 binds VLA4 (a4B1); vascular

22

PECAM

CD 31 binds CD 31 and 38; platelets

23

MadCam

binds mucosal addressin (a4B7); mucosa; important for gut homing

24

NCAM

CD 56 binds VLa4 (a4B1); neuronal

25

chemokine associated with heparin induced thrombocytopenia

CXCL4

26

how is CCR5 related to HIV?

homozygous - NO infection; heterozygous - slow progression

27

CXCR4

considered T trophic in HIV

28

CCL3L1 and HIV

low level leads to higher HIV acquisition, high viral load, worse disease; also known as fractalkine and can predispose to atherosclerosis

29

What is the only x linked complement deficiency?

properidin